> Detailanzeige

Rozenblut-Kościsty, Beata; Ogielska, Maria; Hahn, Juliane; Kleemann, Denise; Kossakowski, Ronja; Tamschick, Stephanie; Schöning, Viola; Krüger, Angela; Lutz, Ilka; Lymberakis, Petros; Kloas, Werner; Stöck, Matthias

Impacts of the synthetic androgen Trenbolone on gonad differentiation and development – comparisons between three deeply diverged anuran families

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Impacts of the synthetic androgen Trenbolone on gonad differentiation and development – comparisons between three deeply diverged anuran families
  • Beteiligte: Rozenblut-Kościsty, Beata; Ogielska, Maria; Hahn, Juliane; Kleemann, Denise; Kossakowski, Ronja; Tamschick, Stephanie; Schöning, Viola; Krüger, Angela; Lutz, Ilka; Lymberakis, Petros; Kloas, Werner; Stöck, Matthias
  • Erschienen: Springer Science and Business Media LLC, 2019
  • Erschienen in: Scientific Reports
  • Sprache: Englisch
  • DOI: 10.1038/s41598-019-45985-4
  • ISSN: 2045-2322
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Using a recently developed approach for testing endocrine disruptive chemicals (EDCs) in amphibians, comprising synchronized tadpole exposure plus genetic and histological sexing of metamorphs in a flow-through-system, we tested the effects of 17β-Trenbolone (Tb), a widely used growth promoter in cattle farming, in three deeply diverged anuran families: the amphibian model species <jats:italic>Xenopus laevis</jats:italic> (Pipidae) and the non-models <jats:italic>Bufo</jats:italic>(<jats:italic>tes</jats:italic>) <jats:italic>viridis</jats:italic> (Bufonidae) and <jats:italic>Hyla arborea</jats:italic> (Hylidae). Trenbolone was applied in three environmentally and/or physiologically relevant concentrations (0.027 µg/L (10<jats:sup>−10</jats:sup> M), 0.27 µg/L (10<jats:sup>−9</jats:sup> M), 2.7 µg/L (10<jats:sup>−8</jats:sup> M)). In none of the species, Tb caused sex reversals or masculinization of gonads but had negative species-specific impacts on gonad morphology and differentiation after the completion of metamorphosis, independently of genetic sex. In <jats:italic>H</jats:italic>. <jats:italic>arborea</jats:italic> and <jats:italic>B</jats:italic>. <jats:italic>viridis</jats:italic>, mounting Tb-concentration correlated positively with anatomical abnormalities at 27 µg/L (10<jats:sup>−9</jats:sup> M) and 2.7 µg/L (10<jats:sup>−8</jats:sup> M), occurring in <jats:italic>X</jats:italic>. <jats:italic>laevis</jats:italic> only at the highest Tb concentration. Despite anatomical aberrations, histologically all gonadal tissues differentiated seemingly normally when examined at the histological level but at various rates. Tb-concentration caused various species-specific mortalities (low in <jats:italic>Xenopus</jats:italic>, uncertain in <jats:italic>Bufo</jats:italic>). Our data suggest that deep phylogenetic divergence modifies EDC-vulnerability, as previously demonstrated for Bisphenol A (BPA) and Ethinylestradiol (EE2).</jats:p>
  • Zugangsstatus: Freier Zugang