> Detailanzeige

Pozarickij, Alfred; Williams, Cathy; Hysi, Pirro G.; Guggenheim, Jeremy A.; Aslam, Tariq; Barman, Sarah A.; Barrett, Jenny H.; Bishop, Paul; Blows, Peter; Bunce, Catey; Carare, Roxana O.; Chakravarthy, Usha; Chan, Michelle; Chua, Sharon Y.L.; Crabb, David P.; Cumberland, Philippa M.; Day, Alexander; Desai, Parul; Dhillon, Bal; Dick, Andrew D.; Egan, Cathy; Ennis, Sarah; Foster, Paul; Fruttiger, Marcus; [...]

Quantile regression analysis reveals widespread evidence for gene-environment or gene-gene interactions in myopia development

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Quantile regression analysis reveals widespread evidence for gene-environment or gene-gene interactions in myopia development
  • Beteiligte: Pozarickij, Alfred; Williams, Cathy; Hysi, Pirro G.; Guggenheim, Jeremy A.; Aslam, Tariq; Barman, Sarah A.; Barrett, Jenny H.; Bishop, Paul; Blows, Peter; Bunce, Catey; Carare, Roxana O.; Chakravarthy, Usha; Chan, Michelle; Chua, Sharon Y.L.; Crabb, David P.; Cumberland, Philippa M.; Day, Alexander; Desai, Parul; Dhillon, Bal; Dick, Andrew D.; Egan, Cathy; Ennis, Sarah; Foster, Paul; Fruttiger, Marcus; [...]
  • Erschienen: Springer Science and Business Media LLC, 2019
  • Erschienen in: Communications Biology
  • Sprache: Englisch
  • DOI: 10.1038/s42003-019-0387-5
  • ISSN: 2399-3642
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>A genetic contribution to refractive error has been confirmed by the discovery of more than 150 associated variants in genome-wide association studies (GWAS). Environmental factors such as education and time outdoors also demonstrate strong associations. Currently however, the extent of gene-environment or gene-gene interactions in myopia is unknown. We tested the hypothesis that refractive error-associated variants exhibit effect size heterogeneity, a hallmark feature of genetic interactions. Of 146 variants tested, evidence of non-uniform, non-linear effects were observed for 66 (45%) at Bonferroni-corrected significance (<jats:italic>P</jats:italic> &lt; 1.1 × 10<jats:sup>−4</jats:sup>) and 128 (88%) at nominal significance (<jats:italic>P</jats:italic> &lt; 0.05). <jats:italic>LAMA2</jats:italic> variant rs12193446, for example, had an effect size varying from −0.20 diopters (95% CI −0.18 to −0.23) to −0.89 diopters (95% CI −0.71 to −1.07) in different individuals. SNP effects were strongest at the phenotype extremes and weaker in emmetropes. A parsimonious explanation for these findings is that gene-environment or gene-gene interactions in myopia are pervasive.</jats:p>
  • Zugangsstatus: Freier Zugang