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Fan, Qiao;
Guo, Xiaobo;
Tideman, J. Willem L.;
Williams, Katie M.;
Yazar, Seyhan;
Hosseini, S. Mohsen;
Howe, Laura D.;
Pourcain, Beaté St;
Evans, David M.;
Timpson, Nicholas J.;
McMahon, George;
Hysi, Pirro G.;
Krapohl, Eva;
Wang, Ya Xing;
Jonas, Jost B.;
Baird, Paul Nigel;
Wang, Jie Jin;
Cheng, Ching-Yu;
Teo, Yik-Ying;
Wong, Tien-Yin;
Ding, Xiaohu;
Wojciechowski, Robert;
Young, Terri L.;
Pärssinen, Olavi;
[...]
Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium
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- Medientyp: E-Artikel
- Titel: Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium
- Beteiligte: Fan, Qiao; Guo, Xiaobo; Tideman, J. Willem L.; Williams, Katie M.; Yazar, Seyhan; Hosseini, S. Mohsen; Howe, Laura D.; Pourcain, Beaté St; Evans, David M.; Timpson, Nicholas J.; McMahon, George; Hysi, Pirro G.; Krapohl, Eva; Wang, Ya Xing; Jonas, Jost B.; Baird, Paul Nigel; Wang, Jie Jin; Cheng, Ching-Yu; Teo, Yik-Ying; Wong, Tien-Yin; Ding, Xiaohu; Wojciechowski, Robert; Young, Terri L.; Pärssinen, Olavi; [...]
- Erschienen: Springer Science and Business Media LLC, 2016
- Erschienen in: Scientific Reports
- Sprache: Englisch
- DOI: 10.1038/srep25853
- ISSN: 2045-2322
- Schlagwörter: Multidisciplinary
- Entstehung:
- Anmerkungen:
- Beschreibung: <jats:title>Abstract</jats:title><jats:p>Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset of association between genetic variants at these 39 loci and refractive error was investigated in 5200 children assessed longitudinally across ages 7–15 years, along with gene-environment interactions involving the major environmental risk-factors, nearwork and time outdoors. Specific variants could be categorized as showing evidence of: (a) early-onset effects remaining stable through childhood, (b) early-onset effects that progressed further with increasing age, or (c) onset later in childhood (N = 10, 5 and 11 variants, respectively). A genetic risk score (GRS) for all 39 variants explained 0.6% (P = 6.6E–08) and 2.3% (P = 6.9E–21) of the variance in refractive error at ages 7 and 15, respectively, supporting increased effects from these genetic variants at older ages. Replication in multi-ancestry samples (combined N = 5599) yielded evidence of childhood onset for 6 of 12 variants present in both Asians and Europeans. There was no indication that variant or GRS effects altered depending on time outdoors, however 5 variants showed nominal evidence of interactions with nearwork (top variant, rs7829127 in <jats:italic>ZMAT4</jats:italic>; P = 6.3E–04).</jats:p>
- Zugangsstatus: Freier Zugang