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Törn, Carina; Liu, Xiang; Hagopian, William; Lernmark, Åke; Simell, Olli; Rewers, Marian; Ziegler, Anette-G; Schatz, Desmond; Akolkar, Beena; Onengut-Gumuscu, Suna; Chen, Wei-Min; Toppari, Jorma; Mykkänen, Juha; Ilonen, Jorma; Rich, Stephen S.; She, Jin-Xiong; Sharma, Ashok; Steck, Andrea; Krischer, Jeffrey; Abbondondolo, Michael; Adams, Janey; Adamsson, Annika; Agardh, Daniel; Anderson, Stephen W.; [...]

Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study

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  • Medientyp: E-Artikel
  • Titel: Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study
  • Beteiligte: Törn, Carina; Liu, Xiang; Hagopian, William; Lernmark, Åke; Simell, Olli; Rewers, Marian; Ziegler, Anette-G; Schatz, Desmond; Akolkar, Beena; Onengut-Gumuscu, Suna; Chen, Wei-Min; Toppari, Jorma; Mykkänen, Juha; Ilonen, Jorma; Rich, Stephen S.; She, Jin-Xiong; Sharma, Ashok; Steck, Andrea; Krischer, Jeffrey; Abbondondolo, Michael; Adams, Janey; Adamsson, Annika; Agardh, Daniel; Anderson, Stephen W.; [...]
  • Erschienen: Springer Science and Business Media LLC, 2016
  • Erschienen in: Scientific Reports
  • Sprache: Englisch
  • DOI: 10.1038/srep27887
  • ISSN: 2045-2322
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>A total of 15 SNPs within complement genes and present on the ImmunoChip were analyzed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. A total of 5474 subjects were followed from three months of age until islet autoimmunity (IA: n = 413) and the subsequent onset of type 1 diabetes (n = 115) for a median of 73 months (IQR 54–91). Three SNPs within <jats:italic>ITGAM</jats:italic> were nominally associated (p &lt; 0.05) with IA: rs1143678 [Hazard ratio; HR 0.80; 95% CI 0.66–0.98; p = 0.032], rs1143683 [HR 0.80; 95% CI 0.65–0.98; p = 0.030] and rs4597342 [HR 1.16; 95% CI 1.01–1.32; p = 0.041]. When type 1 diabetes was the outcome, in DR3/4 subjects, there was nominal significance for two SNPs: rs17615 in <jats:italic>CD21</jats:italic> [HR 1.52; 95% CI 1.05–2.20; p = 0.025] and rs4844573 in <jats:italic>C4BPA</jats:italic> [HR 0.63; 95% CI 0.43–0.92; p = 0.017]. Among DR4/4 subjects, rs2230199 in <jats:italic>C3</jats:italic> was significantly associated [HR 3.20; 95% CI 1.75–5.85; p = 0.0002, uncorrected] a significance that withstood Bonferroni correction since it was less than 0.000833 (0.05/60) in the HLA-specific analyses. SNPs within the complement genes may contribute to IA, the first step to type 1 diabetes, with at least one SNP in <jats:italic>C3</jats:italic> significantly associated with clinically diagnosed type 1 diabetes.</jats:p>
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