Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Exercise Training under Exposure to Low Levels of Fine Particulate Matter: Effects on Heart Oxidative Stress and Extra-to-Intracellular HSP70 Ratio
Beteiligte:
Mai, Aline Sfalcin;
dos Santos, Analu Bender;
Beber, Lílian Corrêa Costa;
Basso, Renan Daniel Bueno;
Sulzbacher, Lucas Machado;
Goettems-Fiorin, Pauline Brendler;
Frizzo, Matias Nunes;
Rhoden, Claudia Ramos;
Ludwig, Mirna Stela;
Heck, Thiago Gomes
Erschienen:
Hindawi Limited, 2017
Erschienen in:Oxidative Medicine and Cellular Longevity
Sprache:
Englisch
DOI:
10.1155/2017/9067875
ISSN:
1942-0900;
1942-0994
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>Fine particulate matter (PM<jats:sub>2.5</jats:sub>) promotes heart oxidative stress (OS) and evokes anti-inflammatory responses observed by increased intracellular 70 kDa heat shock proteins (iHSP70). Furthermore, PM<jats:sub>2.5</jats:sub> increases the levels of these proteins in extracellular fluids (eHSP70), which have proinflammatory roles. We investigated whether moderate and high intensity training under exposure to low levels of PM<jats:sub>2.5</jats:sub> modifies heart OS and the eHSP70 to iHSP70 ratio (H-index), a biomarker of inflammatory status. Male mice (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>32</mml:mn></mml:math>), 30 days old, were divided into six groups for 12 weeks: control (CON), moderate (MIT) and high intensity training (HIT), exposure to 5 <jats:italic>μ</jats:italic>g of PM<jats:sub>2.5</jats:sub> daily (PM<jats:sub>2.5</jats:sub>), and moderate and high intensity training exposed to PM<jats:sub>2.5</jats:sub> (MIT + PM<jats:sub>2.5</jats:sub> and HIT + PM<jats:sub>2.5</jats:sub> groups). The CON and PM<jats:sub>2.5</jats:sub> groups remained sedentary. The MIT + PM<jats:sub>2.5</jats:sub> group showed higher heart lipid peroxidation levels than the MIT and PM<jats:sub>2.5</jats:sub> groups. HIT and HIT + PM<jats:sub>2.5</jats:sub> showed higher heart lipid peroxidation levels and lower eHSP70 and H-index levels compared to sedentary animals. No alterations were found in heart antioxidant enzyme activity or iHSP70 levels. Moderate exercise training under exposure to low levels of PM<jats:sub>2.5</jats:sub> induces heart OS but does not modify eHSP70 to iHSP70 ratio (H-index). High intensity exercise training promotes anti-inflammatory profile despite exposure to low levels of PM<jats:sub>2.5</jats:sub>.</jats:p>