Beschreibung:
<jats:p><jats:italic>Cedecea neteri</jats:italic>, a member of the<jats:italic>Enterobacteriaceae</jats:italic>family, has only been identified as a human pathogen in a few previous clinical cases, thus complicating assessment of this organism’s pathogenicity and medical relevance. Documented infections attributed to<jats:italic>C. neteri</jats:italic>primarily involved bacteremia in severely immunocompromised patients. We report a rare case of urinary catheter colonization by a multidrug-resistant<jats:italic>C. neteri</jats:italic>strain in a patient of advanced age with benign prostatic hyperplasia and other chronic comorbidities. This<jats:italic>C. neteri</jats:italic>isolate was resistant or intermediate to second-generation cephalosporins, penicillins, and certain<jats:italic>β</jats:italic>-lactamase inhibitor/<jats:italic>β</jats:italic>-lactam combinations. Analysis of whole genome sequence information for a representative<jats:italic>C. neteri</jats:italic>strain indicated the presence of multiple open reading frames with sequence similarity to<jats:italic>β</jats:italic>-lactamases, including a chromosome-encoded AmpC<jats:italic>β</jats:italic>-lactamase and metallo-<jats:italic>β</jats:italic>-lactamases, consistent with the resistance phenotype of this bacterium. The presence of an AmpR homolog suggests that the<jats:italic>C. neteri</jats:italic><jats:italic>ampC</jats:italic>may be inducible in response to<jats:italic>β</jats:italic>-lactam exposure. Molecular insights into antibiotic resistance traits of this emerging opportunistic pathogen will be important for administering adequate antibiotic treatment to ensure favorable patient outcomes.</jats:p>