> Detailanzeige

Touzani, Soumaya; Embaslat, Walaa; Imtara, Hamada; Kmail, Abdalsalam; Kadan, Sleman; Zaid, Hilal; ElArabi, Ilham; Badiaa, Lyoussi; Saad, Bashar

In VitroEvaluation of the Potential Use of Propolis as a Multitarget Therapeutic Product: Physicochemical Properties, Chemical Composition, and Immunomodulatory, Antibacterial, and Anticancer Properties

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: In VitroEvaluation of the Potential Use of Propolis as a Multitarget Therapeutic Product: Physicochemical Properties, Chemical Composition, and Immunomodulatory, Antibacterial, and Anticancer Properties
  • Beteiligte: Touzani, Soumaya; Embaslat, Walaa; Imtara, Hamada; Kmail, Abdalsalam; Kadan, Sleman; Zaid, Hilal; ElArabi, Ilham; Badiaa, Lyoussi; Saad, Bashar
  • Erschienen: Hindawi Limited, 2019
  • Erschienen in: BioMed Research International
  • Sprache: Englisch
  • DOI: 10.1155/2019/4836378
  • ISSN: 2314-6133; 2314-6141
  • Schlagwörter: General Immunology and Microbiology ; General Biochemistry, Genetics and Molecular Biology ; General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>Propolis is a resin that honeybees produce by mixing saliva and beeswax with exudate gathered from botanical sources. The present<jats:italic>in vitro</jats:italic>study investigated the potential use of propolis as a multitarget therapeutic product and the physicochemical properties, chemical composition, and immunomodulatory, antioxidant, antibacterial, and anticancer properties of a propolis extract from the northern Morocco region (PNM). Pinocembrin, chrysin, and quercetin were the main phenolic compounds of PNM as measured in HPLC. The PNM showed significant inhibitory effects against all tested Gram-positive and Gram-negative strains and showed high antioxidant activities by scavenging free radicals with IC50 (DPPH = 0.02, ABTS = 0.04, and FRAP = 0.04 mg/ml). In addition, PNM induced a dose-dependent cytostatic effect in MCF-7, HCT, and THP-1 cell lines at noncytotoxic concentrations with IC50 values of 479.22, 108.88, and 50.54 <jats:italic>μ</jats:italic>g/ml, respectively. The production of tumor necrosis factor-<jats:italic>α</jats:italic>(TNF-<jats:italic>α</jats:italic>) and interleukin-6 (IL-6) was decreased in a dose-dependent manner in LPS-stimulated human peripheral blood mononuclear cells (PBMNCs), whereas the production of the anti-inflammatory interleukin-10 (IL-10) was increased in a dose-dependent manner reaching 15-fold compared to the levels measured in untreated PBMNCs. Overall, the results showed that the traditionally known multitarget therapeutic properties of the PNM seem to be mediated, at least in part, through cytostatic, antibacterial, and immunomodulatory effects.</jats:p>
  • Zugangsstatus: Freier Zugang