Keszei, András P.;
Goldbohm, R Alexandra;
Schouten, Leo J.;
Jakszyn, Paula;
Brandt, Piet A. van den
Abstract A99: Dietary N-nitroso compounds, endogenous nitrosation and the risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study
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Medientyp:
E-Artikel
Titel:
Abstract A99: Dietary N-nitroso compounds, endogenous nitrosation and the risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study
Beteiligte:
Keszei, András P.;
Goldbohm, R Alexandra;
Schouten, Leo J.;
Jakszyn, Paula;
Brandt, Piet A. van den
Erschienen:
American Association for Cancer Research (AACR), 2012
Beschreibung:
<jats:title>Abstract</jats:title>
<jats:p>Background: Dietary N-nitroso compounds and endogenous nitrosation are important carcinogenic factors, but evidence for their role from population studies is scarce for esophageal, and inconsistent for gastric cancer.</jats:p>
<jats:p>Objective: We studied the relationship between the risk of esophageal and gastric cancer subtypes and dietary intake of N-nitrosodimethylamine, heme iron, nitrite and nitrate in The Netherlands Cohort Study.</jats:p>
<jats:p>Methods: 120 852 men and women aged 55-69 years were recruited in 1986, and diet, based on a 150-item food frequency questionnaire, as well as other risk factors were assessed. The cohort was followed for 16.3 years, and 110 esophageal squamous cell carcinomas, 151 esophageal adenocarcinomas, 166 gastric cardia adenocarcinomas, and 497 gastric non-cardia adenocarcinoma cases were analyzed along with 4032 subcohort members in a case-cohort analysis.</jats:p>
<jats:p>Results: There were positive associations between N-nitrosodimethylamine intake and esophageal squamous cell carcinoma and gastric non-cardia adenocarcinoma risk in men (hazard ratio (HR) for 0.1 μg/day increase in intake: 1.15 [95% confidence interval (CI): 1.05-1.25; P(trend): 0.01] and 1.06 [95%CI: 1.01-1.10; P(trend): 0.09], respectively). Esophageal squamous cell carcinoma risk was associated with nitrite and heme iron intake (HR for 0.1 mg/day increase in nitrite intake: 1.19 [95%CI: 1.05-1.36; P(trend): 0.06] and for 1 mg/day heme iron intake: 1.83 [95%CI: 0.98-3.39; P(trend): 0.03]). Among women, exposure levels were lower, and we found a positive association only between N-nitrosodimethylamine and esophageal squamous cell carcinoma risk (HR for 0.1 μg/day increase: 1.34 [95%CI: 1.04,1.71; P(trend):0.57]).</jats:p>
<jats:p>Conclusion: These results suggest that N-nitroso compounds and their precursors may influence the risk of esophageal squamous cell carcinoma.</jats:p>
<jats:p>Citation Format: András P. Keszei, R Alexandra Goldbohm, Leo J. Schouten, Paula Jakszyn, Piet A. van den Brandt. Dietary N-nitroso compounds, endogenous nitrosation, and the risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study. [abstract]. In: Proceedings of the Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2012 Oct 16-19; Anaheim, CA. Philadelphia (PA): AACR; Cancer Prev Res 2012;5(11 Suppl):Abstract nr A99.</jats:p>