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Willis, Nathaniel B.; Muñoz, Colleen X.; Mysonhimer, Annemarie R.; Edwards, Caitlyn G.; Wolf, Patricia G.; Hillman, Charles H.; Burd, Nicholas A.; Holscher, Hannah D.; Khan, Naiman A.

Hydration Biomarkers Are Related to the Differential Abundance of Fecal Microbiota and Plasma Lipopolysaccharide-Binding Protein in Adults

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  • Medientyp: E-Artikel
  • Titel: Hydration Biomarkers Are Related to the Differential Abundance of Fecal Microbiota and Plasma Lipopolysaccharide-Binding Protein in Adults
  • Beteiligte: Willis, Nathaniel B.; Muñoz, Colleen X.; Mysonhimer, Annemarie R.; Edwards, Caitlyn G.; Wolf, Patricia G.; Hillman, Charles H.; Burd, Nicholas A.; Holscher, Hannah D.; Khan, Naiman A.
  • Erschienen: S. Karger AG, 2021
  • Erschienen in: Annals of Nutrition and Metabolism
  • Sprache: Englisch
  • DOI: 10.1159/000520478
  • ISSN: 0250-6807; 1421-9697
  • Schlagwörter: Nutrition and Dietetics ; Medicine (miscellaneous)
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Prevalence of chronic hypohydration remains elevated among adults in the USA; however, the health effects of hypohydration in regards to human gut health have not been explored. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; This study examined the relationship between total water intake, hydration biomarkers (first-morning urine specific gravity [FMU&lt;sub&gt;sg&lt;/sub&gt;], first-morning urine volume [FMU&lt;sub&gt;vol&lt;/sub&gt;], and plasma copeptin), fecal microbiota, and plasma lipopolysaccharide-binding protein (LBP) in adults (25–45 years, 64% female). Fecal microbiota composition was assessed using 16S rRNA gene sequencing (V4 region). Immunoassays quantified plasma copeptin and LBP in fasted venous blood samples. Dietary variables were measured using 7-day food records. Linear discriminant analysis effect size (LEfSe) analyzed differentially abundant microbiota based on median cutoffs for hydration markers. Multiple linear regressions examined the relationship between LBP and copeptin. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; LEfSe identified 6 common taxa at the genus or species level that were differentially abundant in FMU&lt;sub&gt;sg&lt;/sub&gt;, total water (g/day), or plasma copeptin (µg/mL) groups when split by their median values. Uncultured species in the &lt;i&gt;Bacteroides&lt;/i&gt;, &lt;i&gt;Desulfovibrio&lt;/i&gt;, &lt;i&gt;Roseburia&lt;/i&gt;, &lt;i&gt;Peptococcus&lt;/i&gt;, and &lt;i&gt;Akkermansia&lt;/i&gt; genera were more abundant in groups that might indicate poorer hydration status. Multivariate linear analyses revealed a positive relationship between plasma copeptin and LBP when controlling confounding variables (&lt;i&gt;F&lt;/i&gt;(6,52) = 4.45, &lt;i&gt;p&lt;/i&gt; = 0.002, &lt;i&gt;R&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; = 0.34). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; Taxa common between markers are associated with the intestinal mucus layer, which suggests a potential link between hydration status and intestinal mucus homeostasis. The relationship between LBP and copeptin indicates that copeptin may be sensitive to metabolic endotoxemia and potentially gut barrier function. </jats:p>