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Friedrich, Anna-Carolina; Linz, Peter; Nagel, Armin M.; Rosenhauer, Daniela; Horn, Stephan; Schiffer, Mario; Uder, Michael; Kopp, Christoph; Dahlmann, Anke

Hemodialysis Patients with Cardiovascular Disease Reveal Increased Tissue Na+ Deposition

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  • Medientyp: E-Artikel
  • Titel: Hemodialysis Patients with Cardiovascular Disease Reveal Increased Tissue Na+ Deposition
  • Beteiligte: Friedrich, Anna-Carolina; Linz, Peter; Nagel, Armin M.; Rosenhauer, Daniela; Horn, Stephan; Schiffer, Mario; Uder, Michael; Kopp, Christoph; Dahlmann, Anke
  • Erschienen: S. Karger AG, 2022
  • Erschienen in: Kidney and Blood Pressure Research
  • Sprache: Englisch
  • DOI: 10.1159/000520821
  • ISSN: 1423-0143; 1420-4096
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; The relationship between Na&lt;sup&gt;+&lt;/sup&gt; balance and cardiovascular disease (CVD) in hemodialysis (HD) patients is not yet fully understood. We hypothesized that HD patients co-diagnosed with CVD show increased tissue Na&lt;sup&gt;+&lt;/sup&gt; accumulation compared to HD patients without CVD. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; In our observational study, 52 HD patients were divided into a group with (23 subjects) or without (29 subjects) a positive history of cardiovascular events. We used &lt;sup&gt;23&lt;/sup&gt;Na-magnetic resonance imaging (&lt;sup&gt;23&lt;/sup&gt;Na-MRI) at 3.0 Tesla to quantify Na&lt;sup&gt;+&lt;/sup&gt; content in skin and muscle of both groups directly before and after HD. Additionally, total body fluid distribution was determined by bioimpedance spectroscopy (BIS) and laboratory parameters were assessed. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Compared to HD patients without CVD, &lt;sup&gt;23&lt;/sup&gt;Na-MRI detected an increased Na&lt;sup&gt;+&lt;/sup&gt; content in skin (21.7 ± 7.3 vs. 30.2 ± 9.8 arbitrary units (a.u.), &lt;i&gt;p&lt;/i&gt; &amp;#x3c; 0.01) and muscle tissue (21.5 ± 3.6 vs. 24.7 ± 6.0 a.u., &lt;i&gt;p&lt;/i&gt; &amp;#x3c; 0.05) in patients with previous CVD events. Simultaneously measured fluid amount by BIS, includingexcess extracellular water (1.8 ± 1.7 vs. 2.2 ± 1.7 L, &lt;i&gt;p&lt;/i&gt; = 0.44), was not significantly different between both groups. Tissue Na&lt;sup&gt;+&lt;/sup&gt; accumulation in HD-CVD patients was paralleled by a higher plasma concentration of the inflammation marker interleukin-6 (5.1, IQR 5.8 vs. 8.5, IQR 7.9 pg/mL, &lt;i&gt;p&lt;/i&gt; &amp;#x3c; 0.05). &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; In our cohort, HD patients with CVD showed higher tissue Na&lt;sup&gt;+&lt;/sup&gt; content than HD patients without CVD, while no difference in body water distribution could be detected between both groups. Our findings provide evidence that the history of a cardiovascular event is associated with disturbances in tissue Na&lt;sup&gt;+&lt;/sup&gt; content in HD patients. </jats:p>
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