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Durstenfeld, Matthew S; Peluso, Michael J; Kaveti, Punita; Hill, Christopher; Li, Danny; Sander, Erica; Swaminathan, Shreya; Arechiga, Victor M; Sun, Kaiwen; Ma, Yifei; zepeda, victor; Lu, Scott; Goldberg, Sarah A; Hoh, Rebecca; Chenna, Ahmed; Yee, Brandon C; Winslow, JOhn W; petropoulos, christos J; Win, Sithu; KELLY, JOHN D; Glidden, David V; Henrich, Timothy J; Martin, Jeffrey N; Lee, Yoo Jin; [...]

Abstract 10570: Inflammation During Early Post-Acute Covid-19 is Associated With Reduced Exercise Capacity and Long Covid Symptoms After 1 Year

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  • Medientyp: E-Artikel
  • Titel: Abstract 10570: Inflammation During Early Post-Acute Covid-19 is Associated With Reduced Exercise Capacity and Long Covid Symptoms After 1 Year
  • Beteiligte: Durstenfeld, Matthew S; Peluso, Michael J; Kaveti, Punita; Hill, Christopher; Li, Danny; Sander, Erica; Swaminathan, Shreya; Arechiga, Victor M; Sun, Kaiwen; Ma, Yifei; zepeda, victor; Lu, Scott; Goldberg, Sarah A; Hoh, Rebecca; Chenna, Ahmed; Yee, Brandon C; Winslow, JOhn W; petropoulos, christos J; Win, Sithu; KELLY, JOHN D; Glidden, David V; Henrich, Timothy J; Martin, Jeffrey N; Lee, Yoo Jin; [...]
  • Erschienen: Ovid Technologies (Wolters Kluwer Health), 2022
  • Erschienen in: Circulation
  • Sprache: Englisch
  • DOI: 10.1161/circ.146.suppl_1.10570
  • ISSN: 0009-7322; 1524-4539
  • Schlagwörter: Physiology (medical) ; Cardiology and Cardiovascular Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p> <jats:bold>Introduction:</jats:bold> Mechanisms underlying cardiopulmonary symptoms following SARS-CoV-2 infection (post-acute sequelae of COVID-19 “PASC” or “Long COVID”) remain unclear. The purpose of this study was to elucidate the pathophysiology of PASC using cardiopulmonary exercise testing (CPET), cardiac magnetic resonance imaging (CMR) and ambulatory rhythm monitoring. </jats:p> <jats:p> <jats:bold>Methods:</jats:bold> We performed CMR, CPET, and ambulatory rhythm monitoring among adults &gt; 1 year after confirmed SARS-CoV-2 infection in the UCSF Long-Term Impact of Infection with Novel Coronavirus cohort (LIINC; NCT04362150) and correlated findings with previously measured biomarkers. We used logistic regression to estimate associations with PASC symptoms and linear regression to estimate differences by symptoms adjusted for confounders. </jats:p> <jats:p> <jats:bold>Results:</jats:bold> Out of 120 participants, 46 participants (unselected for symptom status) had cardiac testing performed at median 17 months after infection. Median age was 52, 18 (39%) were female, and 6 (13%) were hospitalized for severe acute infection. On CPET (n=39), 13/23 (57%) with symptoms had reduced exercise capacity (peak VO2&lt;85% predicted) compared to 2/16 (13%) without symptoms (p=0.008). Adjusted peak VO <jats:sub>2</jats:sub> was 5.9 ml/kg/min lower (-9.6 to -2.3; p=0.002) or -21% predicted (-35 to -7; p=0.006) among those with symptoms. Chronotropic incompetence was present among 9/15 (60%) with reduced peak VO2 (adjusted heart rate reserve&lt;80%: OR 15.6 for reduced peak VO2, 95%CI 1.30-187; p=0.03). Inflammatory markers (hsCRP, IL-6, TNF-α) and SARS-CoV-2 antibody levels measured early in PASC (median 3.5-6 months after infection) were negatively correlated with peak VO2 more than 1 year later (Figure). </jats:p> <jats:p> <jats:bold>Conclusions:</jats:bold> Cardiopulmonary symptoms and elevated inflammatory markers present early in PASC are associated with reduced exercise capacity during CPET &gt;1 year following COVID-19. Chronotropic incompetence may explain reduced exercise capacity among some individuals with PASC. </jats:p> <jats:p> <jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" orientation="portrait" position="float" xlink:href="g10570.jpg" /> </jats:p>
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