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Meybohm, Patrick;
Kohlhaas, Madeline;
Stoppe, Christian;
Gruenewald, Matthias;
Renner, Jochen;
Bein, Berthold;
Albrecht, Martin;
Cremer, Jochen;
Coburn, Mark;
Schaelte, Gereon;
Boening, Andreas;
Niemann, Bernd;
Sander, Michael;
Roesner, Jan;
Kletzin, Frank;
Mutlak, Haitham;
Westphal, Sabine;
Laufenberg‐Feldmann, Rita;
Ferner, Marion;
Brandes, Ivo F.;
Bauer, Martin;
Stehr, Sebastian N.;
Kortgen, Andreas;
Wittmann, Maria;
[...]
RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up
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- Medientyp: E-Artikel
- Titel: RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up
- Beteiligte: Meybohm, Patrick; Kohlhaas, Madeline; Stoppe, Christian; Gruenewald, Matthias; Renner, Jochen; Bein, Berthold; Albrecht, Martin; Cremer, Jochen; Coburn, Mark; Schaelte, Gereon; Boening, Andreas; Niemann, Bernd; Sander, Michael; Roesner, Jan; Kletzin, Frank; Mutlak, Haitham; Westphal, Sabine; Laufenberg‐Feldmann, Rita; Ferner, Marion; Brandes, Ivo F.; Bauer, Martin; Stehr, Sebastian N.; Kortgen, Andreas; Wittmann, Maria; [...]
- Erschienen: Ovid Technologies (Wolters Kluwer Health), 2018
- Erschienen in: Journal of the American Heart Association
- Sprache: Englisch
- DOI: 10.1161/jaha.117.008077
- ISSN: 2047-9980
- Schlagwörter: Cardiology and Cardiovascular Medicine
- Entstehung:
- Anmerkungen:
- Beschreibung: <jats:sec xml:lang="en"> <jats:title>Background</jats:title> <jats:p xml:lang="en"> Remote ischemic preconditioning ( <jats:styled-content style="fixed-case">RIPC</jats:styled-content> ) has been suggested to protect against certain forms of organ injury after cardiac surgery. Previously, we reported the main results of RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study, a multicenter trial randomizing 1403 cardiac surgery patients receiving either <jats:styled-content style="fixed-case">RIPC</jats:styled-content> or sham‐ <jats:styled-content style="fixed-case">RIPC</jats:styled-content> . </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Methods and Results</jats:title> <jats:p xml:lang="en"> In this follow‐up paper, we present 1‐year follow‐up of the composite primary end point and its individual components (all‐cause mortality, myocardial infarction, stroke and acute renal failure), in a sub‐group of patients, intraoperative myocardial dysfunction assessed by transesophageal echocardiography and the incidence of postoperative neurocognitive dysfunction 5 to 7 days and 3 months after surgery. <jats:styled-content style="fixed-case">RIPC</jats:styled-content> neither showed any beneficial effect on the 1‐year composite primary end point ( <jats:styled-content style="fixed-case">RIPC</jats:styled-content> versus sham‐ <jats:styled-content style="fixed-case">RIPC</jats:styled-content> 16.4% versus 16.9%) and its individual components (all‐cause mortality [3.4% versus 2.5%], myocardial infarction [7.0% versus 9.4%], stroke [2.2% versus 3.1%], acute renal failure [7.0% versus 5.7%]) nor improved intraoperative myocardial dysfunction or incidence of postoperative neurocognitive dysfunction 5 to 7 days (67 [47.5%] versus 71 [53.8%] patients) and 3 months after surgery (17 [27.9%] versus 18 [27.7%] patients), respectively. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Conclusions</jats:title> <jats:p xml:lang="en"> Similar to our main study, <jats:styled-content style="fixed-case">RIPC</jats:styled-content> had no effect on intraoperative myocardial dysfunction, neurocognitive function and long‐term outcome in cardiac surgery patients undergoing propofol anesthesia. </jats:p> </jats:sec> <jats:sec xml:lang="en"> <jats:title>Clinical Trial Registration</jats:title> <jats:p xml:lang="en"> URL: <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="https://www.clinicaltrials.gov">https://www.clinicaltrials.gov</jats:ext-link> . Unique identifier: <jats:styled-content style="fixed-case">NCT</jats:styled-content> 01067703. </jats:p> </jats:sec>
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