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Hoffmann, Rüdiger; Rempp, Hansjörg; Schraml, Christina; Schwenzer, Nina; Grözinger, Gerd; Blumenstock, Gunnar; Rothgang, Eva; Pereira, Philippe L; Claussen, Claus D; Clasen, Stephan

Diffusion-weighted imaging during MR-guided radiofrequency ablation of hepatic malignancies: analysis of immediate pre- and post-ablative diffusion characteristics

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  • Medientyp: E-Artikel
  • Titel: Diffusion-weighted imaging during MR-guided radiofrequency ablation of hepatic malignancies: analysis of immediate pre- and post-ablative diffusion characteristics
  • Beteiligte: Hoffmann, Rüdiger; Rempp, Hansjörg; Schraml, Christina; Schwenzer, Nina; Grözinger, Gerd; Blumenstock, Gunnar; Rothgang, Eva; Pereira, Philippe L; Claussen, Claus D; Clasen, Stephan
  • Erschienen: SAGE Publications, 2015
  • Erschienen in: Acta Radiologica
  • Sprache: Englisch
  • DOI: 10.1177/0284185114545148
  • ISSN: 0284-1851; 1600-0455
  • Schlagwörter: Radiology, Nuclear Medicine and imaging ; General Medicine ; Radiological and Ultrasound Technology
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  • Beschreibung: <jats:sec><jats:title>Background</jats:title><jats:p> Previous studies have shown a benefit of magnetic resonance (MR)-diffusion-weighted imaging (DWI) for follow-up after liver radiofrequency (RF) ablation. However, no data are available concerning acute changes of DWI characteristics immediately after RF ablation. </jats:p></jats:sec><jats:sec><jats:title>Purpose</jats:title><jats:p> To analyze and compare the MR-diffusion characteristics of pre-interventional hepatic malignancies and the ablation zone during successful MR-guided RF ablation. </jats:p></jats:sec><jats:sec><jats:title>Material and Methods</jats:title><jats:p> This retrospective study was conducted in accordance with the guidelines of the local institutional review board. Forty-seven patients with 29 HCC (24 patients) and 30 hepatic metastases (23 patients) underwent MR-guided radiofrequency ablation including DWI before and immediately after ablation (b = 50, 400, 800 s/mm<jats:sup>2</jats:sup>). Two reviewers (A and B) analyzed DWI with focus on detectability of the tumor before ablation and characteristics of the coagulative area after treatment. Mean apparent diffusion coefficient (ADC) was compared between liver, untreated tumor, and hyperintense areas in post-ablative DWI (b = 800 s/mm<jats:sup>2</jats:sup>) with the paired Student’s t-test. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Pre-ablative: the reviewers classified 19/29 (A) and 23/29 (B) HCC and 25/30 (A and B) metastases as detectable in DWI. Post-ablative: a hyperintense rim surrounding the ablation zone was observed in 28/29 treated HCC and 30/30 treated metastases (A and B). A homogenous hypointense central ablation zone was found in 18/29 (A) and 20/29 (B) treated HCC and 17/30 (A &amp; B) treated metastases in DWI. ADC of the rim was significantly lower than ADC of the liver ( P &lt; 0.001). </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> DWI enables visualization of the target tumor in MR-guided liver radiofrequency ablation in most cases. A common post-ablative DWI finding is a hyperintense rim with decreased ADC surrounding the ablation zone. </jats:p></jats:sec>