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De Rossi, Anita; Walker, A Sarah; Forni, Davide De; Klein, Nigel; Gibb, Diana M; Aboulker, J-P; Babiker, A; Compagnucci, A; Darbyshire, J; Debré, M; Gersten, M; Giaquinto, C; Gibb, DM; Jones, A; Aboulker, J-P; Babiker, A; Blanche, S; Bohlin, A-B; Butler, K; Castelli-Gattinara, G; Clayden, P; Darbyshire, J; Debré, M; de Groot, R; [...]

Relationship between Changes in Thymic Emigrants and Cell-Associated HIV-1 Dna in HIV-1-Infected Children Initiating Antiretroviral Therapy

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  • Medientyp: E-Artikel
  • Titel: Relationship between Changes in Thymic Emigrants and Cell-Associated HIV-1 Dna in HIV-1-Infected Children Initiating Antiretroviral Therapy
  • Beteiligte: De Rossi, Anita; Walker, A Sarah; Forni, Davide De; Klein, Nigel; Gibb, Diana M; Aboulker, J-P; Babiker, A; Compagnucci, A; Darbyshire, J; Debré, M; Gersten, M; Giaquinto, C; Gibb, DM; Jones, A; Aboulker, J-P; Babiker, A; Blanche, S; Bohlin, A-B; Butler, K; Castelli-Gattinara, G; Clayden, P; Darbyshire, J; Debré, M; de Groot, R; [...]
  • Erschienen: SAGE Publications, 2005
  • Erschienen in: Antiviral Therapy
  • Sprache: Englisch
  • DOI: 10.1177/135965350501000104
  • ISSN: 1359-6535; 2040-2058
  • Schlagwörter: Infectious Diseases ; Pharmacology (medical) ; Pharmacology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Objectives and methods</jats:title><jats:p>To investigate the relationship between cell-associated HIV-1 dynamics and recent thymic T-cell emigrants, HIV-1 DNA and T-cell receptor rearrangement excision circles (TREC, a marker of recent thymic emigrants) were measured in peripheral blood mononuclear cells in 181 samples from 33 HIV-1-infected children followed for 96 weeks after antiretroviral therapy (ART) initiation.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>At baseline, HIV-1 DNA was higher in children with higher TREC ( P=0.02) and was not related to age, CD4 or HIV-1 RNA in multivariate analyses ( P&gt;0.3). Overall, TREC increased and HIV-1 DNA decreased significantly after ART initiation, with faster HIV-1 DNA declines in children with higher baseline TREC ( P=0.009). The greatest decreases in HIV-1 DNA occurred in children with the smallest increases in TREC levels during ART ( P=0.002). However, this inverse relationship between changes in HIV-1 DNA and TREC tended to vary according to the phase of HIV-1 RNA decline ( P=0.13); for the same increase in TREC, HIV-1 DNA decline was much smaller during persistent or transient viraemia compared with stable HIV-1 RNA suppression.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Overall, these findings indicate that TREC levels predict HIV-1 DNA response to ART and suggest that immune repopulation by thymic emigrants adversely affects HIV-1 DNA decline in the absence of persistent viral suppression, possibly by providing a cellular source for viral infection and replication.</jats:p></jats:sec>
  • Zugangsstatus: Freier Zugang