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Otero-Romero, Susana; Lebrun-Frénay, Christine; Reyes, Saúl; Amato, Maria Pia; Campins, Magda; Farez, Mauricio; Filippi, Massimo; Hacohen, Yael; Hemmer, Bernhard; Juuti, Rosa; Magyari, Melinda; Oreja-Guevara, Celia; Siva, Aksel; Vukusic, Sandra; Tintoré, Mar

ECTRIMS/EAN consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs

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  • Medientyp: E-Artikel
  • Titel: ECTRIMS/EAN consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs
  • Beteiligte: Otero-Romero, Susana; Lebrun-Frénay, Christine; Reyes, Saúl; Amato, Maria Pia; Campins, Magda; Farez, Mauricio; Filippi, Massimo; Hacohen, Yael; Hemmer, Bernhard; Juuti, Rosa; Magyari, Melinda; Oreja-Guevara, Celia; Siva, Aksel; Vukusic, Sandra; Tintoré, Mar
  • Erschienen: SAGE Publications, 2023
  • Erschienen in: Multiple Sclerosis Journal
  • Sprache: Englisch
  • DOI: 10.1177/13524585231168043
  • ISSN: 1352-4585; 1477-0970
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Background:</jats:title><jats:p> With the new highly active drugs available for people with multiple sclerosis (pwMS), vaccination becomes an essential part of the risk management strategy </jats:p></jats:sec><jats:sec><jats:title>Objective:</jats:title><jats:p> To develop a European evidence-based consensus for the vaccination strategy of pwMS who are candidates for disease-modifying therapies (DMTs). </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> This work was conducted by a multidisciplinary working group using formal consensus methodology. Clinical questions (defined as population, interventions, and outcomes) considered all authorized DMTs and vaccines. A systematic literature search was conducted and quality of evidence was defined according to the Oxford Centre for Evidence-Based Medicine Levels of Evidence. The recommendations were formulated based on the quality of evidence and the risk–benefit balance. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Seven questions, encompassing vaccine safety, vaccine effectiveness, global vaccination strategy and vaccination in sub-populations (pediatric, pregnant women, elderly and international travelers) were considered. A narrative description of the evidence considering published studies, guidelines, and position statements is presented. A total of 53 recommendations were agreed by the working group after three rounds of consensus. </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> This first European consensus on vaccination in pwMS proposes the best vaccination strategy according to current evidence and expert knowledge, with the goal of homogenizing the immunization practices in pwMS. </jats:p></jats:sec>