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Medientyp:
E-Artikel
Titel:
TREM-1 ligand expression on platelets enhances neutrophil activation
Beteiligte:
Haselmayer, Philipp;
Grosse-Hovest, Ludger;
von Landenberg, Philipp;
Schild, Hansjörg;
Radsak, Markus P.
Erschienen:
American Society of Hematology, 2007
Erschienen in:Blood
Sprache:
Englisch
DOI:
10.1182/blood-2007-01-069195
ISSN:
0006-4971;
1528-0020
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title>
<jats:p>The triggering receptor expressed on myeloid cells 1 (TREM-1) plays an important role in the innate immune response related to severe infections and sepsis. Modulation of TREM-1–associated activation improves the outcome in rodent models for pneumonia and sepsis. However, the identity and occurrence of the natural TREM-1 ligands are so far unknown, impairing the further understanding of the biology of this receptor. Here, we report the presence of a ligand for TREM-1 on human platelets. Using a recombinant TREM-1 fusion protein, we demonstrate specific binding of TREM-1 to platelets. TREM-1–specific signals are required for the platelet-induced augmentation of polymorphonuclear leukocyte (PMN) effector functions (provoked by LPS). However, TREM-1 interaction with its ligand is not required for platelet/PMN complex formation, which is dependent on integrins and selectins. Taken together, the results indicate that the TREM-1 ligand is expressed by platelets, and the TREM-1/ligand interaction contributes to the amplification of LPS-induced PMN activation. Our results shed new light on our understanding of TREM-1 and its role in the innate inflammatory response in infections and might contribute to the development of future concepts to treat sepsis.</jats:p>