> Detailanzeige

Gopal, Ajay K.; Rajendran, Joseph G.; Petersdorf, Stephen H.; Maloney, David G.; Eary, Janet F.; Wood, Brent L.; Gooley, Theodore A.; Bush, Sharon A.; Durack, Lawrence D.; Martin, Paul J.; Matthews, Dana C.; Appelbaum, Frederick R.; Bernstein, Irwin D.; Press, Oliver W.

High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma
  • Beteiligte: Gopal, Ajay K.; Rajendran, Joseph G.; Petersdorf, Stephen H.; Maloney, David G.; Eary, Janet F.; Wood, Brent L.; Gooley, Theodore A.; Bush, Sharon A.; Durack, Lawrence D.; Martin, Paul J.; Matthews, Dana C.; Appelbaum, Frederick R.; Bernstein, Irwin D.; Press, Oliver W.
  • Erschienen: American Society of Hematology, 2002
  • Erschienen in: Blood
  • Sprache: Englisch
  • DOI: 10.1182/blood.v99.9.3158
  • ISSN: 1528-0020; 0006-4971
  • Schlagwörter: Cell Biology ; Hematology ; Immunology ; Biochemistry
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:p>Relapsed mantle cell lymphoma is a radiation-sensitive malignancy that is unlikely to be cured by treatment with conventional high-dose therapy and autologous stem cell transplantation. We tested the safety and efficacy of using a CD20-specific monoclonal antibody conjugated with 131I to deliver high-dose radiation selectively to all lymphoma sites. Patients with relapsed or refractory mantle cell lymphoma received infusions of 131I-labeled CD20-specific monoclonal antibody (Tositumomab). The antibody dose was 1.7 mg/kg body weight, and the amount of 131I was calibrated to deliver 20 to 25 Gy to vital normal organs. This treatment was followed 10 days later by administration of high-dose etoposide (30-60 mg/kg), cyclophosphamide (60-100 mg/kg), and infusion of cryopreserved autologous stem cells. The 16 patients in this study had received a median of 3 prior treatments, and 7 had chemotherapy-resistant disease. The median dose of 131I was 510 mCi (18.87 GBq). There were no therapy-related deaths. Among the 11 patients with conventionally measurable disease at the time of treatment, the respective complete and overall response rates were 91% and 100%. Fifteen patients remain alive, and 12 have had no progression of lymphoma at 6 to 57 months from transplantation and 16 to 97 months from diagnosis. Overall survival at 3 years from transplantation is estimated at 93%, and progression-free survival is estimated at 61%. High-dose treatment with 131I-Tositumomab, etoposide, and cyclophosphamide results in a high remission rate and may provide long-term disease-free survival for patients with relapsed or refractory mantle cell lymphoma.</jats:p>
  • Zugangsstatus: Freier Zugang