> Detailanzeige

García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D’Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizabal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; [...]

METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
  • Beteiligte: García-Vílchez, Raquel; Añazco-Guenkova, Ana M.; Dietmann, Sabine; López, Judith; Morón-Calvente, Virginia; D’Ambrosi, Silvia; Nombela, Paz; Zamacola, Kepa; Mendizabal, Isabel; García-Longarte, Saioa; Zabala-Letona, Amaia; Astobiza, Ianire; Fernández, Sonia; Paniagua, Alejandro; Miguel-López, Borja; Marchand, Virginie; Alonso-López, Diego; Merkel, Angelika; García-Tuñón, Ignacio; Ugalde-Olano, Aitziber; Loizaga-Iriarte, Ana; Lacasa-Viscasillas, Isabel; Unda, Miguel; Azkargorta, Mikel; [...]
  • Erschienen: Springer Science and Business Media LLC, 2023
  • Erschienen in: Molecular Cancer
  • Sprache: Englisch
  • DOI: 10.1186/s12943-023-01809-8
  • ISSN: 1476-4598
  • Schlagwörter: Cancer Research ; Oncology ; Molecular Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. Here, we show that the transfer RNA N<jats:sup>7</jats:sup>-methylguanosine (m<jats:sup>7</jats:sup>G) transferase METTL1 is highly expressed in primary and advanced prostate tumours. Mechanistically, we find that <jats:italic>METTL1</jats:italic> depletion causes the loss of m<jats:sup>7</jats:sup>G tRNA methylation and promotes the biogenesis of a novel class of small non-coding RNAs derived from 5'tRNA fragments. 5'tRNA-derived small RNAs steer translation control to favour the synthesis of key regulators of tumour growth suppression, interferon pathway, and immune effectors. Knockdown of <jats:italic>Mettl1</jats:italic> in prostate cancer preclinical models increases intratumoural infiltration of pro-inflammatory immune cells and enhances responses to immunotherapy. Collectively, our findings reveal a therapeutically actionable role of METTL1-directed m<jats:sup>7</jats:sup>G tRNA methylation in cancer cell translation control and tumour biology.</jats:p>
  • Zugangsstatus: Freier Zugang