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Strauss, Franz Josef; Stähli, Alexandra; Gruber, Reinhard

The use of platelet‐rich fibrin to enhance the outcomes of implant therapy: A systematic review

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  • Medientyp: E-Artikel
  • Titel: The use of platelet‐rich fibrin to enhance the outcomes of implant therapy: A systematic review
  • Beteiligte: Strauss, Franz Josef; Stähli, Alexandra; Gruber, Reinhard
  • Erschienen: Wiley, 2018
  • Erschienen in: Clinical Oral Implants Research
  • Sprache: Englisch
  • DOI: 10.1111/clr.13275
  • ISSN: 0905-7161; 1600-0501
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To assess the impact of platelet‐rich fibrin (<jats:styled-content style="fixed-case">PRF</jats:styled-content>) on implant dentistry. The primary focused question was as follows: What are the clinical, histological, and radiographic outcomes of <jats:styled-content style="fixed-case">PRF</jats:styled-content> administration for bone regeneration and implant therapy?</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>A systematic literature search comprised three databases: <jats:styled-content style="fixed-case">MEDLINE</jats:styled-content>,<jats:styled-content style="fixed-case"> EMBASE</jats:styled-content>, and Cochrane followed by a hand search of relevant scientific journals. Human studies using <jats:styled-content style="fixed-case">PRF</jats:styled-content> for bone regeneration and implant therapy were considered and articles published up to December 31, 2017 were included. Eligible studies were selected based on the inclusion criteria. Randomized controlled trials (<jats:styled-content style="fixed-case">RCT</jats:styled-content>) and controlled clinical trials (<jats:styled-content style="fixed-case">CCT</jats:styled-content>) were included.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In total, 5,963 titles were identified with the search terms and by hand search. A total of 12 randomized controlled trials (<jats:styled-content style="fixed-case">RCT</jats:styled-content>) met the inclusion criteria and were chosen for data extraction. Included studies focused on alveolar ridge preservation after tooth extraction, osseointegration process, soft tissue management, bone augmentation, bone regeneration after sinus floor elevation and surgical peri‐implantitis treatment. Overall, the risk of bias was moderate or unclear. Nine studies showed superior outcomes for <jats:styled-content style="fixed-case">PRF</jats:styled-content> for any of the evaluated variables, such as ridge dimension, bone regeneration, osseointegration process, soft tissue healing. Three studies failed to show any beneficial effects of <jats:styled-content style="fixed-case">PRF</jats:styled-content>. No meta‐analysis could be performed due to the heterogeneity of study designs.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>There is moderate evidence supporting the clinical benefit of <jats:styled-content style="fixed-case">PRF</jats:styled-content> on ridge preservation and in the early phase of osseointegration. It remains unclear whether <jats:styled-content style="fixed-case">PRF</jats:styled-content> can reduce pain and improve soft tissue healing. More research support is necessary to comment on the role of <jats:styled-content style="fixed-case">PRF</jats:styled-content> to improve other implant therapy outcomes.</jats:p></jats:sec>