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<jats:p> <jats:bold>Citation</jats:bold> Toth B, Haufe T, Scholz C, Kuhn C, Friese K, Karamouti M, Makrigiannakis A, Jeschke U. Placental Interleukin‐15 expression in recurrent miscarriage. Am J Reprod Immunol 2010; 64: 402–410</jats:p><jats:p><jats:bold>Problem </jats:bold> Cytokines play a fundamental role at the feto–maternal interface. A dysregulation of the cytokine profile could be linked with fetal rejection. This study investigated differences in the expression of the Th1 cytokine interleukin‐15 (IL‐15) of normal and disturbed pregnancy.</jats:p><jats:p><jats:bold>Method of study </jats:bold> Analysis of IL‐15 expression by immunohistochemistry and real‐time RT‐PCR in placental tissue from normal pregnancies, spontaneous miscarriage and recurrent miscarriage (RM) was performed.</jats:p><jats:p><jats:bold>Results </jats:bold> Expression of IL‐15 was upregulated on mRNA and protein level in the placenta of miscarriage patients, especially in patients with RM. Immunohistochemistry and immunofluorescence double staining revealed extravillous trophoblast cells (EVT) as IL‐15‐expressing cells. Staining results were confirmed by real‐time PCR (TaqMan).</jats:p><jats:p><jats:bold>Conclusion </jats:bold> Increased expression of IL‐15 in the decidua of patients with RM may be linked to disturbed implantation and vascularization with consecutive placental and fetal rejection.</jats:p>