> Detailanzeige

Gacek, Paul; Conner, Tamlin S.; Tennen, Howard; Kranzler, Henry R.; Covault, Jonathan

GENETIC STUDY: Tryptophan hydroxylase 2 gene and alcohol use among college students

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: GENETIC STUDY: Tryptophan hydroxylase 2 gene and alcohol use among college students
  • Beteiligte: Gacek, Paul; Conner, Tamlin S.; Tennen, Howard; Kranzler, Henry R.; Covault, Jonathan
  • Erschienen: Wiley, 2008
  • Erschienen in: Addiction Biology
  • Sprache: Englisch
  • DOI: 10.1111/j.1369-1600.2008.00118.x
  • ISSN: 1355-6215; 1369-1600
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>ABSTRACT</jats:title><jats:p>Genes that regulate serotonin activity are regarded as promising predictors of heavy alcohol use. <jats:italic>Tryptophan hydroxylase</jats:italic> (<jats:italic>TPH2</jats:italic>) plays an important role in serotonergic neurotransmission by serving as the rate‐limiting enzyme for serotonin biosynthesis in the midbrain and serotonergic neurons. Despite the link between <jats:italic>TPH2</jats:italic> and serotonergic function, <jats:italic>TPH2</jats:italic>'s role in the pathogenesis of alcohol‐use disorders remains unclear. The goal of this study was to examine whether a variation in the <jats:italic>TPH2</jats:italic> gene is associated with risky alcohol consumption. Specifically, this study examined whether the <jats:italic>TPH2</jats:italic> G‐703T polymorphism predicted alcohol consumption among college students. In two successive years, 351 undergraduates were asked to record their alcohol use each day for 30 days using an Internet‐based electronic diary. Participants' DNA was collected and polymerase chain reaction genotyping was performed. Results show that alcohol consumption was not associated with the <jats:italic>TPH2</jats:italic> G‐703T polymorphism alone, or the interaction of <jats:italic>TPH2</jats:italic> with two other candidate polymorphisms (<jats:italic>TPH1</jats:italic> C218A and the <jats:italic>SLC6A4</jats:italic> tri‐allelic 5‐HTTLPR), or negative life events. In conclusion, this study supports recent null findings relating <jats:italic>TPH2</jats:italic> to drinking outcomes. It also extends these findings by showing null interactions with the <jats:italic>TPH1</jats:italic> C218A polymorphism, the <jats:italic>SLC6A4</jats:italic> tri‐allelic 5‐HTTLPR polymorphism and environmental stressors in predicting sub‐clinical alcohol use among Caucasian American young adults.</jats:p>