Adverse Events in Mobility‐Limited and Chronically Ill Elderly Adults Participating in an Exercise Intervention Study Supported by General Practitioner Practices
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Medientyp:
E-Artikel
Titel:
Adverse Events in Mobility‐Limited and Chronically Ill Elderly Adults Participating in an Exercise Intervention Study Supported by General Practitioner Practices
Beschreibung:
<jats:sec><jats:title>Objectives</jats:title><jats:p>To present detailed adverse event (<jats:styled-content style="fixed-case">AE</jats:styled-content>) data from a randomized controlled trial (<jats:styled-content style="fixed-case">RCT</jats:styled-content>) of a home‐based exercise program delivered to an elderly high‐risk population by an exercise therapist after medical clearance from a general practitioner (<jats:styled-content style="fixed-case">GP</jats:styled-content>).</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Randomized controlled trial.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>General practitioner practices and participant homes.</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>Community‐dwelling, chronically ill, mobility‐limited individuals aged 70 and older (mean 80 ± 5) participating in a <jats:styled-content style="fixed-case">RCT</jats:styled-content> of an exercise program (<jats:styled-content style="fixed-case">HOME</jats:styled-content>fit; <jats:styled-content style="fixed-case">ISRCTN</jats:styled-content>17727272) (N = 209; n = 106 experimental, n = 103 control; 74% female).</jats:p></jats:sec><jats:sec><jats:title>Intervention</jats:title><jats:p>A 12‐week multidimensional home‐based exercise program (experimental) versus baseline physical activity counseling (control). An exercise therapist delivered both interventions to participants during counseling sessions at the <jats:styled-content style="fixed-case">GP</jats:styled-content>'s practice and on the telephone.</jats:p></jats:sec><jats:sec><jats:title>Measurements</jats:title><jats:p>Adverse events were documented at least at every counseling session and assessed by the <jats:styled-content style="fixed-case">GP</jats:styled-content> and an <jats:styled-content style="fixed-case">AE</jats:styled-content> manager.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>One hundred fifty‐one <jats:styled-content style="fixed-case">AE</jats:styled-content>s were reported in 47% (n = 99) of all participants. Twenty‐one (14%) events were classified as serious. In six events (4%; n = 4 experimental, n = 2 control), participation in the study had to be discontinued immediately. In 25 events (17%; n = 9 experimental, n = 16 control), the intervention had to be suspended. The intervention was determined to have caused two events (both nonserious and in the experimental group).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Even though the program appears to be safe, high morbidity unrelated to exercise can constitute a critical challenge for sustained exercise participation.</jats:p></jats:sec>