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Kunst, Stefanie; Wolloscheck, Tanja; Hölter, Philip; Wengert, Alexander; Grether, Markus; Sticht, Carsten; Weyer, Veronika; Wolfrum, Uwe; Spessert, Rainer

Transcriptional analysis of rat photoreceptor cells reveals daily regulation of genes important for visual signaling and light damage susceptibility

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  • Medientyp: E-Artikel
  • Titel: Transcriptional analysis of rat photoreceptor cells reveals daily regulation of genes important for visual signaling and light damage susceptibility
  • Beteiligte: Kunst, Stefanie; Wolloscheck, Tanja; Hölter, Philip; Wengert, Alexander; Grether, Markus; Sticht, Carsten; Weyer, Veronika; Wolfrum, Uwe; Spessert, Rainer
  • Erschienen: Wiley, 2013
  • Erschienen in: Journal of Neurochemistry
  • Sprache: Englisch
  • DOI: 10.1111/jnc.12089
  • ISSN: 0022-3042; 1471-4159
  • Schlagwörter: Cellular and Molecular Neuroscience ; Biochemistry
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Photoreceptor cells face the challenge of adjusting their function and, possibly, their susceptibility to light damage to the marked daily changes in ambient light intensity. To achieve a better understanding of photoreceptor adaptation at the transcriptional level, this study aimed to identify genes which are under daily regulation in photoreceptor cells using microarray analysis and quantitative <jats:styled-content style="fixed-case">PCR</jats:styled-content>. Included in the gene set obtained were a number of genes which up until now have not been shown to be expressed in photoreceptor cells, such as <jats:italic>Atf3</jats:italic> (<jats:italic>activating transcription factor 3</jats:italic>) and <jats:italic>Pde8a</jats:italic> (<jats:italic>phosphodiesterase 8A</jats:italic>), and others with a known impact on phototransduction and/or photoreceptor survival, such as <jats:italic>Grk1</jats:italic> (<jats:italic>G protein‐coupled receptor kinase 1</jats:italic>) and <jats:italic>Pgc‐1α</jats:italic> (<jats:italic>peroxisome proliferator‐activated receptor γ, coactivator 1alpha</jats:italic>). According to their daily dynamics, the genes identified could be clustered in two groups: those with peak expression during the second part of the day which are uniformly promoted to cycle by light/dark transitions and those with peak expression during the second part of the night which are predominately driven by a clock. Since <jats:italic>Grk1</jats:italic> and <jats:italic>Pgc‐1α</jats:italic> belong in the first group, the present results support a concept in which transcriptional regulation of genes by ambient light contributes to the functional adjustment of photoreceptor cells over the 24‐h period.</jats:p>
  • Zugangsstatus: Freier Zugang