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Pacey, Verity; Tofts, Louise; Adams, Roger D; Munns, Craig F; Nicholson, Leslie L

Quality of life prediction in children with joint hypermobility syndrome

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  • Medientyp: E-Artikel
  • Titel: Quality of life prediction in children with joint hypermobility syndrome
  • Beteiligte: Pacey, Verity; Tofts, Louise; Adams, Roger D; Munns, Craig F; Nicholson, Leslie L
  • Erschienen: Wiley, 2015
  • Erschienen in: Journal of Paediatrics and Child Health
  • Sprache: Englisch
  • DOI: 10.1111/jpc.12826
  • ISSN: 1034-4810; 1440-1754
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  • Beschreibung: <jats:sec><jats:title>Aims</jats:title><jats:p>To assess the child‐ and parent‐reported health‐related quality of life (<jats:styled-content style="fixed-case">HRQOL</jats:styled-content>) of children with joint hypermobility syndrome (<jats:styled-content style="fixed-case">JHS</jats:styled-content>), to compare these with other chronic paediatric conditions and to determine whether symptoms experienced by children with <jats:styled-content style="fixed-case">JHS</jats:styled-content> can predict their <jats:styled-content style="fixed-case">HRQOL</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Eighty‐nine children with JHS and one of their parents completed the Pediatric Quality of Life Inventory 4.0 Generic Core Scale, the Multidimensional Fatigue Scale and the Pediatric Pain Questionnaire. Anthropometric measures and reported symptoms were recorded. Child‐reported <jats:styled-content style="fixed-case">HRQOL</jats:styled-content> scores were compared with parent report, and both child‐ and parent‐reported <jats:styled-content style="fixed-case">HRQOL</jats:styled-content> scores of children with <jats:styled-content style="fixed-case">JHS</jats:styled-content> were compared with those of children with other chronic conditions. Stepwise multiple regression was undertaken to determine whether any combination of measures could predict <jats:styled-content style="fixed-case">HRQOL</jats:styled-content>.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Parent‐ and child‐reported <jats:styled-content style="fixed-case">HRQOL</jats:styled-content> scores were strongly correlated (<jats:italic>r</jats:italic> = 0.6–0.84, all <jats:italic>P</jats:italic> &lt; 0.001); however, parents of children with <jats:styled-content style="fixed-case">JHS</jats:styled-content> perceived lower overall <jats:styled-content style="fixed-case">HRQOL</jats:styled-content> (mean difference = 4.44, <jats:italic>P</jats:italic> = 0.001), physical (mean difference = 7.11, <jats:italic>P</jats:italic> &lt; 0.0001) and emotional functioning (mean difference = 5.24, <jats:italic>P</jats:italic> = 0.011) than their children. When considered together with previously reported <jats:styled-content style="fixed-case">HRQOL</jats:styled-content> scores for children with other chronic conditions, parent and child scores were similarly strongly correlated (<jats:italic>r</jats:italic> = 0.93, <jats:italic>P</jats:italic> = 0.001). Multiple regression revealed that 75% of the variance in child‐reported <jats:styled-content style="fixed-case">HRQOL</jats:styled-content> scores was accounted for by a child's level of pain and fatigue, and presence of stress incontinence symptoms (<jats:italic>P</jats:italic> &lt; 0.0001).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Children with <jats:styled-content style="fixed-case">JHS</jats:styled-content> experience poor <jats:styled-content style="fixed-case">HRQOL</jats:styled-content> and disabling fatigue, with parent scores providing a good proxy. Pain, fatigue and the presence of stress incontinence symptoms have the greatest impact on their <jats:styled-content style="fixed-case">HRQOL</jats:styled-content>.</jats:p></jats:sec>