Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Anticoagulant rodenticides (<jats:styled-content style="fixed-case">AR</jats:styled-content>s) are indiscriminate toxicants that threaten nontarget predatory and scavenger species through secondary poisoning. Accumulating evidence suggests that <jats:styled-content style="fixed-case">AR</jats:styled-content> exposure may have disruptive sublethal consequences on individuals that can affect fitness. We evaluated <jats:styled-content style="fixed-case">AR</jats:styled-content>‐related effects on genome‐wide expression patterns in a population of bobcats in southern California. We identify differential expression of genes involved in xenobiotic metabolism, endoplasmic reticulum stress response, epithelial integrity and both adaptive and innate immune function. Further, we find that differential expression of immune‐related genes may be attributable to <jats:styled-content style="fixed-case">AR</jats:styled-content>‐related effects on leucocyte differentiation. Collectively, our results provide an unprecedented understanding of the sublethal effects of <jats:styled-content style="fixed-case">AR</jats:styled-content> exposure on a wild carnivore. These findings highlight potential detrimental effects of <jats:styled-content style="fixed-case">AR</jats:styled-content>s on a wide variety of species worldwide that may consume poisoned rodents and indicate the need to investigate gene expression effects of other toxicants added to natural environments by humans.</jats:p>