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Robinson, Makeda L.; Glass, David R.; Duran, Veronica; Agudelo Rojas, Olga Lucia; Sanz, Ana Maria; Consuegra, Monika; Sahoo, Malaya Kumar; Hartmann, Felix J.; Bosse, Marc; Gelvez, Rosa Margarita; Bueno, Nathalia; Pinsky, Benjamin A.; Montoya, Jose G.; Maecker, Holden; Estupiñan Cardenas, Maria Isabel; Villar Centeno, Luis Angel; Garrido, Elsa Marina Rojas; Rosso, Fernando; Bendall, Sean C.; Einav, Shirit

Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics

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  • Medientyp: E-Artikel
  • Titel: Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics
  • Beteiligte: Robinson, Makeda L.; Glass, David R.; Duran, Veronica; Agudelo Rojas, Olga Lucia; Sanz, Ana Maria; Consuegra, Monika; Sahoo, Malaya Kumar; Hartmann, Felix J.; Bosse, Marc; Gelvez, Rosa Margarita; Bueno, Nathalia; Pinsky, Benjamin A.; Montoya, Jose G.; Maecker, Holden; Estupiñan Cardenas, Maria Isabel; Villar Centeno, Luis Angel; Garrido, Elsa Marina Rojas; Rosso, Fernando; Bendall, Sean C.; Einav, Shirit
  • Erschienen: American Association for the Advancement of Science (AAAS), 2023
  • Erschienen in: Science Advances
  • Sprache: Englisch
  • DOI: 10.1126/sciadv.ade7702
  • ISSN: 2375-2548
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p> Approximately 5 million dengue virus–infected patients progress to a potentially life-threatening severe dengue (SD) infection annually. To identify the immune features and temporal dynamics underlying SD progression, we performed deep immune profiling by mass cytometry of PBMCs collected longitudinally from SD progressors (SDp) and uncomplicated dengue (D) patients. While D is characterized by early activation of innate immune responses, in SDp there is rapid expansion and activation of IgG-secreting plasma cells and memory and regulatory T cells. Concurrently, SDp, particularly children, demonstrate increased proinflammatory NK cells, inadequate expansion of CD16 <jats:sup>+</jats:sup> monocytes, and high expression of the FcγR CD64 on myeloid cells, yet a signature of diminished antigen presentation. Syndrome-specific determinants include suppressed dendritic cell abundance in shock/hemorrhage versus enriched plasma cell expansion in organ impairment. This study reveals uncoordinated immune responses in SDp and provides insights into SD pathogenesis in humans with potential implications for prediction and treatment. </jats:p>
  • Zugangsstatus: Freier Zugang