Fisch, Paul;
Malkovsky, Miroslav;
Kovats, Susan;
Sturm, Els;
Braakman, Erik;
Klein, Bruce S.;
Voss, Stephan D.;
Morrissey, Lawrence W.;
DeMars, Robert;
Welch, William J.;
Bolhuis, Reinder L. H.;
Sondel, Paul M.
Recognition by Human V γ 9/V δ 2 T Cells of a GroEL Homolog on Daudi Burkitt's Lymphoma Cells
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Medientyp:
E-Artikel
Titel:
Recognition by Human V γ 9/V δ 2 T Cells of a GroEL Homolog on Daudi Burkitt's Lymphoma Cells
Beteiligte:
Fisch, Paul;
Malkovsky, Miroslav;
Kovats, Susan;
Sturm, Els;
Braakman, Erik;
Klein, Bruce S.;
Voss, Stephan D.;
Morrissey, Lawrence W.;
DeMars, Robert;
Welch, William J.;
Bolhuis, Reinder L. H.;
Sondel, Paul M.
Erschienen:
American Association for the Advancement of Science (AAAS), 1990
Erschienen in:Science
Sprache:
Englisch
DOI:
10.1126/science.1978758
ISSN:
0036-8075;
1095-9203
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>
All human γδ T cells coexpressing the products of the variable (V) region T cell receptor (TCR) gene segments V
<jats:sub>γ</jats:sub>
9 and V
<jats:sub>δ</jats:sub>
2 recognize antigens from some mycobacterial extracts and Daudi cells. Exogenous and endogenous ligands on the cell surface, homologous to the groEL heat shock family, induced reactivities that resembled superantigen responses in this major subset of human peripheral blood γδ T cells. Stimulation of human V
<jats:sub>γ</jats:sub>
9/V
<jats:sub>δ</jats:sub>
2 T cells is not restricted by human leukocyte antigens (HLA), including nonpolymorphic β
<jats:sub>2</jats:sub>
-microglobulin (β
<jats:sub>2</jats:sub>
M)-associated class Ib molecules. These data may be important for understanding the role of γδ T cells in autoimmunity and in responses to microorganisms and tumors.
</jats:p>