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Pizza, Mariagrazia; Scarlato, Vincenzo; Masignani, Vega; Giuliani, Marzia Monica; Aricò, Beatrice; Comanducci, Maurizio; Jennings, Gary T.; Baldi, Lucia; Bartolini, Erika; Capecchi, Barbara; Galeotti, Cesira L.; Luzzi, Enrico; Manetti, Roberto; Marchetti, Elisa; Mora, Marirosa; Nuti, Sandra; Ratti, Giulio; Santini, Laura; Savino, Silvana; Scarselli, Maria; Storni, Elisa; Zuo, Peijun; Broeker, Michael; Hundt, Erika; [...]

Identification of Vaccine Candidates Against Serogroup B Meningococcus by Whole-Genome Sequencing

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  • Medientyp: E-Artikel
  • Titel: Identification of Vaccine Candidates Against Serogroup B Meningococcus by Whole-Genome Sequencing
  • Beteiligte: Pizza, Mariagrazia; Scarlato, Vincenzo; Masignani, Vega; Giuliani, Marzia Monica; Aricò, Beatrice; Comanducci, Maurizio; Jennings, Gary T.; Baldi, Lucia; Bartolini, Erika; Capecchi, Barbara; Galeotti, Cesira L.; Luzzi, Enrico; Manetti, Roberto; Marchetti, Elisa; Mora, Marirosa; Nuti, Sandra; Ratti, Giulio; Santini, Laura; Savino, Silvana; Scarselli, Maria; Storni, Elisa; Zuo, Peijun; Broeker, Michael; Hundt, Erika; [...]
  • Erschienen: American Association for the Advancement of Science (AAAS), 2000
  • Erschienen in: Science
  • Sprache: Englisch
  • DOI: 10.1126/science.287.5459.1816
  • ISSN: 0036-8075; 1095-9203
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p> <jats:italic>Neisseria meningitidis</jats:italic> is a major cause of bacterial septicemia and meningitis <jats:italic>.</jats:italic> Sequence variation of surface-exposed proteins and cross-reactivity of the serogroup B capsular polysaccharide with human tissues have hampered efforts to develop a successful vaccine. To overcome these obstacles, the entire genome sequence of a virulent serogroup B strain (MC58) was used to identify vaccine candidates. A total of 350 candidate antigens were expressed in <jats:italic>Escherichia coli</jats:italic> , purified, and used to immunize mice. The sera allowed the identification of proteins that are surface exposed, that are conserved in sequence across a range of strains, and that induce a bactericidal antibody response, a property known to correlate with vaccine efficacy in humans. </jats:p>