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Fluckiger, Aurélie; Daillère, Romain; Sassi, Mohamed; Sixt, Barbara Susanne; Liu, Peng; Loos, Friedemann; Richard, Corentin; Rabu, Catherine; Alou, Maryam Tidjani; Goubet, Anne-Gaëlle; Lemaitre, Fabien; Ferrere, Gladys; Derosa, Lisa; Duong, Connie P. M.; Messaoudene, Meriem; Gagné, Andréanne; Joubert, Philippe; De Sordi, Luisa; Debarbieux, Laurent; Simon, Sylvain; Scarlata, Clara-Maria; Ayyoub, Maha; Palermo, Belinda; Facciolo, Francesco; [...]

Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage

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  • Medientyp: E-Artikel
  • Titel: Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage
  • Beteiligte: Fluckiger, Aurélie; Daillère, Romain; Sassi, Mohamed; Sixt, Barbara Susanne; Liu, Peng; Loos, Friedemann; Richard, Corentin; Rabu, Catherine; Alou, Maryam Tidjani; Goubet, Anne-Gaëlle; Lemaitre, Fabien; Ferrere, Gladys; Derosa, Lisa; Duong, Connie P. M.; Messaoudene, Meriem; Gagné, Andréanne; Joubert, Philippe; De Sordi, Luisa; Debarbieux, Laurent; Simon, Sylvain; Scarlata, Clara-Maria; Ayyoub, Maha; Palermo, Belinda; Facciolo, Francesco; [...]
  • Erschienen: American Association for the Advancement of Science (AAAS), 2020
  • Erschienen in: Science
  • Sprache: Englisch
  • DOI: 10.1126/science.aax0701
  • ISSN: 0036-8075; 1095-9203
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Phages and cancer immunity</jats:title> <jats:p> Gut bacteria are involved in the education of T cell immune responses, and the intestinal ecosystem influences anticancer immunity. Fluckiger <jats:italic>et al.</jats:italic> report microbial antigens that might cross-react with antigens associated with tumor cells. They found that a type of intestinal bacteria called enterococci harbor a bacteriophage that modulates immune responses. In mouse models, administration of enterococci containing the bacteriophage boosted T cell responses after treatment with chemotherapy or programmed cell death protein 1 (PD-1) blockade. In humans, the presence of the bacteriophage was associated with improved survival after PD-1 immunotherapy. A fraction of human T cells specific for naturally processed melanoma epitopes appeared to be able to recognize microbial peptides. This “molecular mimicry” may represent cross-reactivity between tumors and microbial antigens. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6506" page="936" related-article-type="in-this-issue" vol="369" xlink:href="10.1126/science.aax0701">936</jats:related-article> </jats:p>