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Berkow, Elizabeth L.; Nunnally, Natalie S.; Bandea, Alex; Kuykendall, Randall; Beer, Karlyn; Lockhart, Shawn R.

Detection of TR 34 /L98H CYP51A Mutation through Passive Surveillance for Azole-Resistant Aspergillus fumigatus in the United States from 2015 to 2017

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  • Medientyp: E-Artikel
  • Titel: Detection of TR 34 /L98H CYP51A Mutation through Passive Surveillance for Azole-Resistant Aspergillus fumigatus in the United States from 2015 to 2017
  • Beteiligte: Berkow, Elizabeth L.; Nunnally, Natalie S.; Bandea, Alex; Kuykendall, Randall; Beer, Karlyn; Lockhart, Shawn R.
  • Erschienen: American Society for Microbiology, 2018
  • Erschienen in: Antimicrobial Agents and Chemotherapy
  • Sprache: Englisch
  • DOI: 10.1128/aac.02240-17
  • ISSN: 0066-4804; 1098-6596
  • Schlagwörter: Infectious Diseases ; Pharmacology (medical) ; Pharmacology
  • Entstehung:
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  • Beschreibung: <jats:title>ABSTRACT</jats:title> <jats:p> The emergence of azole-resistant <jats:named-content content-type="genus-species">Aspergillus fumigatus</jats:named-content> has become a clinical problem in many parts of the world. Several amino acid mutations in the azole target protein Cyp51Ap contribute to this resistance, with the most concerning being the environmentally derived TR <jats:sub>34</jats:sub> /L98H and TR <jats:sub>46</jats:sub> /Y121F/T289A mutations. Here, we performed passive surveillance to assess a sample of the <jats:named-content content-type="genus-species">A. fumigatus</jats:named-content> population in the United States for the presence of these mutations. We found 1.4% of those isolates to exhibit elevated MIC via broth microdilution, and five of those isolates harbored the TR <jats:sub>34</jats:sub> /L98H mutation. </jats:p>
  • Zugangsstatus: Freier Zugang