Creasey, Alison M.;
Staalsoe, Trine;
Raza, Ahmed;
Arnot, David E.;
Rowe, J. Alexandra
Nonspecific Immunoglobulin M Binding and Chondroitin Sulfate A Binding Are Linked Phenotypes of Plasmodium falciparum Isolates Implicated in Malaria during Pregnancy
Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Nonspecific Immunoglobulin M Binding and Chondroitin Sulfate A Binding Are Linked Phenotypes of Plasmodium falciparum Isolates Implicated in Malaria during Pregnancy
Beteiligte:
Creasey, Alison M.;
Staalsoe, Trine;
Raza, Ahmed;
Arnot, David E.;
Rowe, J. Alexandra
Erschienen:
American Society for Microbiology, 2003
Beschreibung:
<jats:title>ABSTRACT</jats:title>
<jats:p>
Binding of immunoglobulin M (IgM) antibodies from normal human serum to the surface of
<jats:italic>Plasmodium falciparum</jats:italic>
-infected red blood cells (iRBC) has previously been demonstrated only in parasites that form rosettes with uninfected red cells. We show that natural, nonspecific IgM but not IgG, IgA, IgD, or IgE also binds to the surface of iRBC selected for adhesion to chondroitin sulfate A (CSA), a placental receptor for parasites associated with malaria in pregnancy. The protease sensitivity of IgM-binding appears to match that of CSA binding, suggesting that the two phenotypes may be mediated by the same parasite molecule. We also show that a wide range of mouse monoclonal antibodies of the IgM class bind nonspecifically to CSA-selected iRBC, an important consideration in the interpretation of immunological assays performed on these parasite lines.
</jats:p>