• Medientyp: E-Artikel
  • Titel: Two-Component Nanoparticle Vaccine Displaying Glycosylated Spike S1 Domain Induces Neutralizing Antibody Response against SARS-CoV-2 Variants
  • Beteiligte: van Oosten, Linda; Altenburg, Jort J.; Fougeroux, Cyrielle; Geertsema, Corinne; van den End, Fred; Evers, Wendy A. C.; Westphal, Adrie H.; Lindhoud, Simon; van den Berg, Willy; Swarts, Daan C.; Deurhof, Laurens; Suhrbier, Andreas; Le, Thuy T.; Torres Morales, Shessy; Myeni, Sebenzile K.; Kikkert, Marjolein; Sander, Adam F.; de Jongh, Willem Adriaan; Dagil, Robert; Nielsen, Morten A.; Salanti, Ali; Søgaard, Max; Keijzer, Timo M. P.; Weijers, Dolf; [...]
  • Erschienen: American Society for Microbiology, 2021
  • Erschienen in: mBio
  • Sprache: Englisch
  • DOI: 10.1128/mbio.01813-21
  • ISSN: 2150-7511
  • Schlagwörter: Virology ; Microbiology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:p>Vaccines pave the way out of the SARS-CoV-2 pandemic. We have developed a virus-like particle (VLP)-based vaccine using the baculovirus-insect cell expression system, a robust production platform known for its scalability, low cost, and safety. Baculoviruses were constructed encoding SARS-CoV-2 spike proteins: full-length S, stabilized secreted S, or the S1 domain. This two-component nanoparticle vaccine can now be further developed to help alleviate the burden of COVID-19.</jats:p>
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