The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species

Medientyp: E-Artikel
Titel: The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species
Beteiligte: Schmoll, Monika; Dattenböck, Christoph; Carreras-Villaseñor, Nohemí; Mendoza-Mendoza, Artemio; Tisch, Doris; Alemán, Mario Ivan; Baker, Scott E.; Brown, Christopher; Cervantes-Badillo, Mayte Guadalupe; Cetz-Chel, José; Cristobal-Mondragon, Gema Rosa; Delaye, Luis; Esquivel-Naranjo, Edgardo Ulises; Frischmann, Alexa; Gallardo-Negrete, Jose de Jesus; García-Esquivel, Monica; Gomez-Rodriguez, Elida Yazmin; Greenwood, David R.; Hernández-Oñate, Miguel; Kruszewska, Joanna S.; Lawry, Robert; Mora-Montes, Hector M.; Muñoz-Centeno, Tania; Nieto-Jacobo, Maria Fernanda; [...]
Erschienen: American Society for Microbiology, 2016
Erschienen in: Microbiology and Molecular Biology Reviews
Sprache: Englisch
DOI: 10.1128/mmbr.00040-15
ISSN: 1092-2172; 1098-5557
Schlagwörter: Molecular Biology ; Microbiology ; Infectious Diseases
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Beschreibung: <jats:title>SUMMARY</jats:title> <jats:p> The genus <jats:named-content content-type="genus-species">Trichoderma</jats:named-content> contains fungi with high relevance for humans, with applications in enzyme production for plant cell wall degradation and use in biocontrol. Here, we provide a broad, comprehensive overview of the genomic content of these species for “hot topic” research aspects, including CAZymes, transport, transcription factors, and development, along with a detailed analysis and annotation of less-studied topics, such as signal transduction, genome integrity, chromatin, photobiology, or lipid, sulfur, and nitrogen metabolism in <jats:named-content content-type="genus-species">T. reesei</jats:named-content> , <jats:named-content content-type="genus-species">T. atroviride</jats:named-content> , and <jats:named-content content-type="genus-species">T. virens</jats:named-content> , and we open up new perspectives to those topics discussed previously. In total, we covered more than 2,000 of the predicted 9,000 to 11,000 genes of each <jats:named-content content-type="genus-species">Trichoderma</jats:named-content> species discussed, which is >20% of the respective gene content. Additionally, we considered available transcriptome data for the annotated genes. Highlights of our analyses include overall carbohydrate cleavage preferences due to the different genomic contents and regulation of the respective genes. We found light regulation of many sulfur metabolic genes. Additionally, a new Golgi 1,2-mannosidase likely involved in <jats:italic>N</jats:italic> -linked glycosylation was detected, as were indications for the ability of <jats:named-content content-type="genus-species">Trichoderma</jats:named-content> spp. to generate hybrid galactose-containing <jats:italic>N</jats:italic> -linked glycans. The genomic inventory of effector proteins revealed numerous compounds unique to <jats:named-content content-type="genus-species">Trichoderma</jats:named-content> , and these warrant further investigation. We found interesting expansions in the <jats:named-content content-type="genus-species">Trichoderma</jats:named-content> genus in several signaling pathways, such as G-protein-coupled receptors, RAS GTPases, and casein kinases. A particularly interesting feature absolutely unique to <jats:named-content content-type="genus-species">T. atroviride</jats:named-content> is the duplication of the alternative sulfur amino acid synthesis pathway. </jats:p>
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