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Komatsu, Junji; Samuraki, Miharu; Nakajima, Kenichi; Arai, Heii; Arai, Hiroyuki; Arai, Tetsuaki; Asada, Takashi; Fujishiro, Hiroshige; Hanyu, Haruo; Iizuka, Osamu; Iseki, Eizo; Kashihara, Kenichi; Kosaka, Kenji; Maruno, Hirotaka; Mizukami, Katsuyoshi; Mizuno, Yoshikuni; Mori, Etsuro; Nakamura, Hiroyuki; Nakano, Seigo; Nakashima, Kenji; Nishio, Yoshiyuki; Orimo, Satoshi; Takahashi, Akira; Taki, Junichi; [...]

123I-MIBG myocardial scintigraphy for the diagnosis of DLB: a multicentre 3-year follow-up study

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  • Medientyp: E-Artikel
  • Titel: 123I-MIBG myocardial scintigraphy for the diagnosis of DLB: a multicentre 3-year follow-up study
  • Beteiligte: Komatsu, Junji; Samuraki, Miharu; Nakajima, Kenichi; Arai, Heii; Arai, Hiroyuki; Arai, Tetsuaki; Asada, Takashi; Fujishiro, Hiroshige; Hanyu, Haruo; Iizuka, Osamu; Iseki, Eizo; Kashihara, Kenichi; Kosaka, Kenji; Maruno, Hirotaka; Mizukami, Katsuyoshi; Mizuno, Yoshikuni; Mori, Etsuro; Nakamura, Hiroyuki; Nakano, Seigo; Nakashima, Kenji; Nishio, Yoshiyuki; Orimo, Satoshi; Takahashi, Akira; Taki, Junichi; [...]
  • Erschienen: BMJ, 2018
  • Erschienen in: Journal of Neurology, Neurosurgery & Psychiatry
  • Sprache: Englisch
  • DOI: 10.1136/jnnp-2017-317398
  • ISSN: 0022-3050; 1468-330X
  • Schlagwörter: Psychiatry and Mental health ; Neurology (clinical) ; Surgery
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  • Beschreibung: <jats:sec><jats:title>Background and purpose</jats:title><jats:p>We previously reported the usefulness of iodine-123 metaiodobenzylguanidine (<jats:sup>123</jats:sup>I-MIBG) myocardial scintigraphy for differentiation of dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD) in a cross-sectional multicentre study. The aim of this study was, by using reassessed diagnosis after 3-year follow-up, to evaluate the diagnostic accuracy of <jats:sup>123</jats:sup>I-MIBG scintigraphy in differentiation of probable DLB from probable AD.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We undertook 3-year follow-up of 133 patients with probable or possible DLB or probable AD who had undergone <jats:sup>123</jats:sup>I-MIBG myocardial scintigraphy at baseline. An independent consensus panel made final diagnosis at 3-year follow-up. Based on the final diagnosis, we re-evaluated the diagnostic accuracy of <jats:sup>123</jats:sup>I-MIBG scintigraphy performed at baseline.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Sixty-five patients completed 3-year follow-up assessment. The final diagnoses were probable DLB (n=30), possible DLB (n=3) and probably AD (n=31), and depression (n=1). With a receiver operating characteristic curve analysis of heart-to-mediastinum (H/M) ratios for differentiating probable DLB from probable AD, the sensitivity/specificity were 0.77/0.94 for early images using 2.51 as the threshold of early H/M ratio, and 0.77/0.97 for delayed images using 2.20 as the threshold of delayed H/M ratio. Five of six patients who were diagnosed with possible DLB at baseline and with probable DLB at follow-up had low H/M ratio at baseline.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Our follow-up study confirmed high correlation between abnormal cardiac sympathetic activity evaluated with <jats:sup>123</jats:sup>I-MIBG myocardial scintigraphy at baseline and the clinical diagnosis of probable DLB at 3-year follow-up. Its diagnostic usefulness in early stage of DLB was suggested.</jats:p></jats:sec><jats:sec><jats:title>Trial registration number</jats:title><jats:p>UMIN00003419.</jats:p></jats:sec>