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van Vollenhoven, Ronald F; Bertsias, George; Doria, Andrea; Isenberg, David; Morand, Eric; Petri, Michelle A; Pons-Estel, Bernardo A; Rahman, Anisur; Ugarte-Gil, Manuel Francisco; Voskuyl, Alexandre; Arnaud, Laurent; Bruce, Ian N; Cervera, Ricard; Costedoat-Chalumeau, Nathalie; Gordon, Caroline; Houssiau, Frédéric A; Mosca, Marta; Schneider, Matthias; Ward, Michael M; Alarcon, Graciela; Aringer, Martin; Askanase, Anca D; Bae, Sang-Cheol; Bootsma, Hendrika; [...]

2021 DORIS definition of remission in SLE: final recommendations from an international task force

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  • Medientyp: E-Artikel
  • Titel: 2021 DORIS definition of remission in SLE: final recommendations from an international task force
  • Beteiligte: van Vollenhoven, Ronald F; Bertsias, George; Doria, Andrea; Isenberg, David; Morand, Eric; Petri, Michelle A; Pons-Estel, Bernardo A; Rahman, Anisur; Ugarte-Gil, Manuel Francisco; Voskuyl, Alexandre; Arnaud, Laurent; Bruce, Ian N; Cervera, Ricard; Costedoat-Chalumeau, Nathalie; Gordon, Caroline; Houssiau, Frédéric A; Mosca, Marta; Schneider, Matthias; Ward, Michael M; Alarcon, Graciela; Aringer, Martin; Askanase, Anca D; Bae, Sang-Cheol; Bootsma, Hendrika; [...]
  • Erschienen: BMJ, 2021
  • Erschienen in: Lupus Science & Medicine
  • Sprache: Englisch
  • DOI: 10.1136/lupus-2021-000538
  • ISSN: 2053-8790
  • Schlagwörter: Immunology ; General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Objective</jats:title><jats:p>To achieve consensus on a definition of remission in SLE (DORIS).</jats:p></jats:sec><jats:sec><jats:title>Background</jats:title><jats:p>Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator’s Global Assessment &lt;0.5 (0–3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.</jats:p></jats:sec>
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