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Medientyp:
E-Artikel
Titel:
Chlamydia psittaci Infection in Nongastrointestinal Extranodal MALT Lymphomas and Their Precursor Lesions
Beteiligte:
Aigelsreiter, Ariane;
Gerlza, Tanja;
Deutsch, Alexander J.A.;
Leitner, Eva;
Beham-Schmid, Christine;
Beham, Alfred;
Popper, Helmut;
Borel, Nicole;
Pospischil, Andreas;
Raderer, Markus;
Kessler, Harald H.;
Neumeister, Peter
Erschienen:
Oxford University Press (OUP), 2011
Erschienen in:American Journal of Clinical Pathology
Sprache:
Englisch
DOI:
10.1309/ajcpxmdrt1sy6kiv
ISSN:
1943-7722;
0002-9173
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title>
<jats:p>Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) are associated with various infectious pathogens. We analyzed the presence of Chlamydia psittaci, Chlamydia pneumoniae, and Chlamydia trachomatis DNA in 47 nongastrointestinal and 14 gastrointestinal MALT lymphomas, 37 nonmalignant control samples, and 27 autoimmune precursor lesions by polymerase chain reaction amplification and direct sequencing.</jats:p>
<jats:p>In 47 nongastrointestinal MALT lymphomas, 13 (28%) were positive for C psittaci DNA compared with 4 (11%) of 37 nonmalignant control samples (P = .09). C psittaci was detected at variable frequencies in MALT lymphomas of different sites: lung, 100% (5/5; P &lt; .01); thyroid gland, 30% (3/10; P &gt; .05); salivary gland, 13% (2/15; P &gt; .05); ocular adnexa, 15% (2/13); and skin, 25% (1/4). Of 27 autoimmune precursor lesions (11 Hashimoto thyroiditis and 16 Sjögren syndrome), 11 (41%) contained C psittaci DNA. Only 1 (7%) of 14 gastrointestinal MALT lymphomas was positive for C psittaci. All specimens were negative for C trachomatis and C pneumoniae.</jats:p>
<jats:p>Besides ocular adnexal lymphomas, C psittaci infection is associated with nongastrointestinal MALT lymphomas and autoimmune precursor lesions, suggesting possible involvement of C psittaci–induced antigenic-driven MALT lymphomagenesis.</jats:p>