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Obermeier, Martin; Pacenti, Monia; Ehret, Robert; Onelia, Francesco; Gunson, Rory; Goldstein, Emily; Chevaliez, Stéphane; Vilas, Alba; Glass, Allison; Maree, Leana; Krügel, Maria; Knechten, Heribert; Braun, Patrick; Naeth, Gudrun; Azzato, Francesca; Lucic, Danijela; Marlowe, Natalia; Palm, Michael John; Pfeifer, Karin; Reinhardt, Birgit; Dhein, Jens; Joseph, Ajith Mathew; Martínez-García, Laura; Galán, Juan-Carlos

Improved molecular laboratory productivity by consolidation of testing on the new random-access analyzer Alinity m

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  • Medientyp: E-Artikel
  • Titel: Improved molecular laboratory productivity by consolidation of testing on the new random-access analyzer Alinity m
  • Beteiligte: Obermeier, Martin; Pacenti, Monia; Ehret, Robert; Onelia, Francesco; Gunson, Rory; Goldstein, Emily; Chevaliez, Stéphane; Vilas, Alba; Glass, Allison; Maree, Leana; Krügel, Maria; Knechten, Heribert; Braun, Patrick; Naeth, Gudrun; Azzato, Francesca; Lucic, Danijela; Marlowe, Natalia; Palm, Michael John; Pfeifer, Karin; Reinhardt, Birgit; Dhein, Jens; Joseph, Ajith Mathew; Martínez-García, Laura; Galán, Juan-Carlos
  • Erschienen: Walter de Gruyter GmbH, 2020
  • Erschienen in: Journal of Laboratory Medicine
  • Sprache: Englisch
  • DOI: 10.1515/labmed-2020-0102
  • ISSN: 2567-9449; 2567-9430
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:sec id="j_labmed-2020-0102_abs_001"> <jats:title>Objectives</jats:title> <jats:p>Automated molecular analyzers have accelerated diagnosis, allowing earlier intervention and better patient follow-up. A recently developed completely automated molecular analyzer, Alinity™ m (Abbott), offers consolidated, continuous, and random-access testing that may improve molecular laboratory workflow.</jats:p> </jats:sec> <jats:sec id="j_labmed-2020-0102_abs_002"> <jats:title>Methods</jats:title> <jats:p>An international, multicenter study compared laboratory workflow metrics across various routine analyzers and Alinity m utilizing assays for human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV), hepatitis B virus (HBV), high-risk human papillomavirus (HR HPV), and sexually transmitted infection (STI) (<jats:italic>Chlamydia trachomatis</jats:italic> [CT]/<jats:italic>Neisseria gonorrhoeae</jats:italic> [NG]/<jats:italic>Trichomonas vaginalis</jats:italic> [TV]/<jats:italic>Mycoplasma genitalium</jats:italic> [MG]). Three turnaround times (TATs) were assessed: total TAT (sample arrival to result), sample onboard TAT (sample loading and test starting to result), and processing TAT (sample aspiration to result).</jats:p> </jats:sec> <jats:sec id="j_labmed-2020-0102_abs_003"> <jats:title>Results</jats:title> <jats:p>Total TAT was reduced from days with routine analyzers to hours with Alinity m, independent of requested assays. Sample onboard TATs for standard workflow using routine analyzers ranged from 7 to 32.5 h compared to 2.75–6 h for Alinity m. The mean sample onboard TAT for STAT samples on Alinity m was 2.36 h (±0.19 h). Processing TATs for Alinity m were independent of the combination of assays, with 100% of results reported within 117 min.</jats:p> </jats:sec> <jats:sec id="j_labmed-2020-0102_abs_004"> <jats:title>Conclusions</jats:title> <jats:p>The consolidated, continuous, random-access workflow of Alinity m reduces TATs across various assays and is expected to improve both laboratory operational efficiency and patient care.</jats:p> </jats:sec>
  • Zugangsstatus: Freier Zugang