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Seddighi, Reza; Elliot, Sarah B.; Whitlock, Brian K.; Egger, Christine M.; Doherty, Tom J.

Physiologic and antinociceptive effects following intramuscular administration of xylazine hydrochloride in combination with tiletamine-zolazepam in llamas

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  • Medientyp: E-Artikel
  • Titel: Physiologic and antinociceptive effects following intramuscular administration of xylazine hydrochloride in combination with tiletamine-zolazepam in llamas
  • Beteiligte: Seddighi, Reza; Elliot, Sarah B.; Whitlock, Brian K.; Egger, Christine M.; Doherty, Tom J.
  • Erschienen: American Veterinary Medical Association (AVMA), 2013
  • Erschienen in: American Journal of Veterinary Research
  • Sprache: Nicht zu entscheiden
  • DOI: 10.2460/ajvr.74.4.530
  • ISSN: 0002-9645
  • Schlagwörter: General Veterinary ; General Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:p><jats:bold>Objective</jats:bold>—To evaluate antinociceptive and selected effects associated with IM administration of xylazine hydrochloride in combination with tiletamine-zolazepam in llamas.</jats:p> <jats:p><jats:bold>Animals</jats:bold>—8 adult male llamas.</jats:p> <jats:p><jats:bold>Procedures</jats:bold>—Each llama received tiletamine-zolazepam (2 mg/kg) combined with either xylazine (0.1, 0.2, or 0.4 mg/kg) or saline (0.9% NaCl) solution IM (treatments designated as TZ-Xy0.1, TZ-Xy0.2, TZ-Xy0.4, and TZ-Sal, respectively) at 1-week intervals. Selected cardiorespiratory variables were assessed during lateral recumbency and anesthesia, and recovery characteristics were recorded. Duration of antinociception was evaluated by clamping a claw every 5 minutes.</jats:p> <jats:p><jats:bold>Results</jats:bold>—Interval between treatment administration and lateral recumbency for TZ-Xy0.4 was shorter than that for TZ-Xy0.1 or TZ-Sal. Mean ± SEM duration of antinociception was longer for TZ-Xy0.4 (51.3 ± 7. 0 minutes), compared with findings for TZ-Xy0.2 (31.9 ± 6.0 minutes), TZ-Xy0.1 (8.1 ± 4.0 minutes), and TZ-Sal (0.6 ± 0.6 minutes). Interval between treatment administration and standing was longer for TZ-Xy0.4 (112 ± 9 minutes) than it was for TZ-Xy0.2 (77 ± 9 minutes) or TZ-Sal (68 ± 9 minutes). Mean heart and respiratory rates during the first 30 minutes for TZ-Sal exceeded values for the other treatments. Administration of TZ-Xy0.2 and TZ-Xy0.4 resulted in Pa<jats:sc>o</jats:sc><jats:sub>2</jats:sub> &lt; 60 mm Hg at 5 minutes after llamas attained lateral recumbency, and values differed from TZ-Sal findings at 5, 10, and 15 minutes; Pa<jats:sc>co</jats:sc><jats:sub>2</jats:sub> was greater for TZ-Xy0.2 and TZ-Xy0.4 than for TZ-Sal at 5, 10, 15, and 20 minutes.</jats:p> <jats:p><jats:bold>Conclusions and Clinical Relevance</jats:bold>—Xylazine (0.2 and 0.4 mg/kg) increased the duration of antinociception in llamas anesthetized with tiletamine-zolazepam.</jats:p>
  • Zugangsstatus: Freier Zugang