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Tofflemire, Kyle L.; Whitley, Elizabeth M.; Allbaugh, Rachel A.; Ben-Shlomo, Gil; Robinson, Casey C.; Overton, Taryn L.; Thiessen, Charlotte E.; Evans, Erin A.; Griggs, Angel N.; Adelman, Sara A.; Ludwig, Allison L.; Jens, Jackie K.; Ellinwood, N. Matthew; Peterson, Chimene S.; Whitley, R. David

Comparison of two- and three-times-daily topical ophthalmic application of 0.005% latanoprost solution in clinically normal dogs

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  • Medientyp: E-Artikel
  • Titel: Comparison of two- and three-times-daily topical ophthalmic application of 0.005% latanoprost solution in clinically normal dogs
  • Beteiligte: Tofflemire, Kyle L.; Whitley, Elizabeth M.; Allbaugh, Rachel A.; Ben-Shlomo, Gil; Robinson, Casey C.; Overton, Taryn L.; Thiessen, Charlotte E.; Evans, Erin A.; Griggs, Angel N.; Adelman, Sara A.; Ludwig, Allison L.; Jens, Jackie K.; Ellinwood, N. Matthew; Peterson, Chimene S.; Whitley, R. David
  • Erschienen: American Veterinary Medical Association (AVMA), 2015
  • Erschienen in: American Journal of Veterinary Research
  • Sprache: Nicht zu entscheiden
  • DOI: 10.2460/ajvr.76.7.625
  • ISSN: 0002-9645
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:p><jats:bold>OBJECTIVE</jats:bold> To determine whether 2- or 3-times-daily application of topical ophthalmic 0.005% latanoprost solution is more effective at lowering intraocular pressure (IOP) in clinically normal dogs.</jats:p> <jats:p><jats:bold>ANIMALS</jats:bold> 9 clinically normal dogs.</jats:p> <jats:p><jats:bold>PROCEDURES</jats:bold> For each dog, I drop of latanoprost 0.005% solution was applied to 1 eye every 8 or 12 hours each day for 5 days; the contralateral eye received topical ophthalmic treatment with 1 drop of saline (0.9% NaCl) solution at the times of latanoprost application. Ocular examinations of both eyes were performed every 6 hours starting 48 hours prior to and ending 42 hours after the treatment period. Following a 5-week washout interval, the procedures were repeated but the previously latanoprost-treated eye of each dog received latanoprost application at the alternate frequency.</jats:p> <jats:p><jats:bold>RESULTS</jats:bold> Mean ± SD IOP reduction in the latanoprost-treated eyes was 31 ± 6.9% with 2-times-daily application and 33 ± 8.2% with 3-times-daily application. A 2-way repeated-measures ANOVA revealed significant differences in IOP with contributions by treatment (2 or 3 times daily), time of day (diurnal variation), and individual dog. The maximum mean daily IOP reduction in latanoprost-treated eyes was detected on day 3 of latanoprost treatment in each group. Eyes treated 3 times daily had significantly smaller pupil diameter and greater conjunctival hyperemia than eyes treated 2 times daily.</jats:p> <jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE</jats:bold> The clinical importance of the ocular hypotensive effects of 3-times-daily topical ophthalmic application of 0.005% latanoprost solution in dogs with glaucoma warrants investigation.</jats:p>
  • Zugangsstatus: Freier Zugang