Beschreibung:
<jats:title>Abstract</jats:title>
<jats:p>Little is known about the pharmacological activities of <jats:italic>Iris adriatica</jats:italic> (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using <jats:italic>Mycobacterium smegmatis</jats:italic> mc<jats:sup>2</jats:sup> 155. One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L<jats:sup>−1</jats:sup>. Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone, responsible for the resistance-modulatory activity of this plant.</jats:p>