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Spada, Enea; Simeoni, Matteo; Martina, Antonio; Pati, Ilaria; Villano, Umbertina; Adriani, Daniela; D’Angiò, Agnese; Tritarelli, Elena; Taffon, Stefania; Bellino, Stefania; Boros, Stefano; Urciuoli, Roberta; Masiello, Francesca; Marano, Giuseppe; Bruni, Roberto; Pezzotti, Patrizio; Ciccaglione, Anna Rita; Pupella, Simonetta; De Angelis, Vincenzo; Pisani, Giulio

Prevalence and risk factors for hepatitis E virus infection in blood donors: a nationwide survey in Italy, 2017 to 2019

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  • Medientyp: E-Artikel
  • Titel: Prevalence and risk factors for hepatitis E virus infection in blood donors: a nationwide survey in Italy, 2017 to 2019
  • Beteiligte: Spada, Enea; Simeoni, Matteo; Martina, Antonio; Pati, Ilaria; Villano, Umbertina; Adriani, Daniela; D’Angiò, Agnese; Tritarelli, Elena; Taffon, Stefania; Bellino, Stefania; Boros, Stefano; Urciuoli, Roberta; Masiello, Francesca; Marano, Giuseppe; Bruni, Roberto; Pezzotti, Patrizio; Ciccaglione, Anna Rita; Pupella, Simonetta; De Angelis, Vincenzo; Pisani, Giulio
  • Erschienen: European Centre for Disease Control and Prevention (ECDC), 2022
  • Erschienen in: Eurosurveillance
  • Sprache: Englisch
  • DOI: 10.2807/1560-7917.es.2022.27.22.2100516
  • ISSN: 1560-7917
  • Schlagwörter: Virology ; Public Health, Environmental and Occupational Health ; Epidemiology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Background</jats:title><jats:p>In high-income countries, hepatitis E virus (HEV) infection is mainly a zoonosis. However, it is also transfusion-transmissible and some countries, but not Italy, have introduced HEV screening for blood donations.</jats:p></jats:sec><jats:sec><jats:title>Aim</jats:title><jats:p>We assessed HEV infection prevalence and risk factors in a nationwide sample of Italian blood donors.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We selected 107 blood establishments (BE) distributed in the 20 Italian regions by a stratified two-stage design and invited them to participate in the study. Donors were tested for anti-HEV IgG and IgM and HEV RNA. Sociodemographic data and risk factors were collected through a questionnaire.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Overall, 60 BE from 60 provinces in 19 Italian regions joined the study. We assessed HEV markers in 7,172 blood donors, of whom 6,235 completed the questionnaire. Overall crude and adjusted anti-HEV IgG prevalences were 8.3% and 5.5%, respectively. Overall anti-HEV IgM prevalence was 0.5%, while no blood donor was HEV RNA-positive. Anti-HEV IgG prevalence varied widely among regions (range: 1.3%–27.20%) and hyperendemic prevalences (&gt; 40%) were detected in some provinces in two regions. Older age (AOR = 1.81; 95% CI: 1.36–2.41), foreign nationality (AOR = 2.77; 95% CI: 1.06–7.24), eating raw pork liver sausages (AOR = 2.23; 95% CI: 1.55–3.20) and raw homemade sausages (AOR = 3.63; 95% CI: 2.50–5.24) were independent infection predictors.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Italian blood donors showed a low to moderate HEV seroprevalence. High levels in some regions and/or provinces were mainly attributable to eating habits. Prevention should include avoiding consumption of raw or undercooked meat and safe production of commercial pork products.</jats:p></jats:sec>
  • Zugangsstatus: Freier Zugang