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De Michele, Manuela; Lorenzano, Svetlana; Piscopo, Paola; Rivabene, Roberto; Crestini, Alessio; Chistolini, Antonio; Stefanini, Lucia; Pulcinelli, Fabio M.; Berto, Irene; Campagna, Roberta; Amisano, Paolo; Iacobucci, Marta; Cirelli, Carlo; Falcou, Anne; Nicolini, Ettore; Schiavo, Oscar G.; Toni, Danilo

SARS-CoV-2 infection predicts larger infarct volume in patients with acute ischemic stroke

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  • Medientyp: E-Artikel
  • Titel: SARS-CoV-2 infection predicts larger infarct volume in patients with acute ischemic stroke
  • Beteiligte: De Michele, Manuela; Lorenzano, Svetlana; Piscopo, Paola; Rivabene, Roberto; Crestini, Alessio; Chistolini, Antonio; Stefanini, Lucia; Pulcinelli, Fabio M.; Berto, Irene; Campagna, Roberta; Amisano, Paolo; Iacobucci, Marta; Cirelli, Carlo; Falcou, Anne; Nicolini, Ettore; Schiavo, Oscar G.; Toni, Danilo
  • Erschienen: Frontiers Media SA, 2023
  • Erschienen in: Frontiers in Cardiovascular Medicine
  • Sprache: Nicht zu entscheiden
  • DOI: 10.3389/fcvm.2022.1097229
  • ISSN: 2297-055X
  • Schlagwörter: Cardiology and Cardiovascular Medicine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Background and purpose</jats:title><jats:p>Acute ischemic stroke (AIS) is a fearful complication of Coronavirus Disease-2019 (COVID-19). Aims of this study were to compare clinical/radiological characteristics, endothelial and coagulation dysfunction between acute ischemic stroke (AIS) patients with and without COVID-19 and to investigate if and how the SARS-CoV-2 spike protein (SP) was implicated in triggering platelet activation.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We enrolled AIS patients with COVID-19 within 12 h from onset and compared them with an age- and sex-matched cohort of AIS controls without COVID-19. Neuroimaging studies were performed within 24 h. Blood samples were collected in a subset of 10 patients.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 39 AIS patients, 22 had COVID-19 and 17 did not. Admission levels of Factor VIII and von Willebrand factor antigen were significantly higher in COVID-19 patients and positively correlated with the infarct volume. In multivariate linear regression analyses, COVID-19 was an independent predictor of infarct volume (B 20.318, Beta 0.576, 95%CI 6.077–34.559; <jats:italic>p</jats:italic> = 0.011). SP was found in serum of 2 of the 10 examined COVID-19 patients. Platelets from healthy donors showed a similar degree of procoagulant activation induced by COVID-19 and non-COVID-19 patients' sera. The anti-SP and anti-FcγRIIA blocking antibodies had no effect in modulating platelet activity in both groups.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>SARS-CoV-2 infection seems to play a major role in endothelium activation and infarct volume extension during AIS.</jats:p></jats:sec>
  • Zugangsstatus: Freier Zugang