Blomberg, Rina;
Signoret, Carine;
Danielsson, Henrik;
Perini, Irene;
Rönnberg, Jerker;
Capusan, Andrea Johansson
Aberrant resting-state connectivity of auditory, ventral attention/salience and default-mode networks in adults with attention deficit hyperactivity disorder
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Medientyp:
E-Artikel
Titel:
Aberrant resting-state connectivity of auditory, ventral attention/salience and default-mode networks in adults with attention deficit hyperactivity disorder
Beteiligte:
Blomberg, Rina;
Signoret, Carine;
Danielsson, Henrik;
Perini, Irene;
Rönnberg, Jerker;
Capusan, Andrea Johansson
Beschreibung:
<jats:sec><jats:title>Background</jats:title><jats:p>Numerous resting-state studies on attention deficit hyperactivity disorder (ADHD) have reported aberrant functional connectivity (FC) between the default-mode network (DMN) and the ventral attention/salience network (VA/SN). This finding has commonly been interpreted as an index of poorer DMN regulation associated with symptoms of mind wandering in ADHD literature. However, a competing perspective suggests that dysfunctional organization of the DMN and VA/SN may additionally index increased sensitivity to the external environment. The goal of the current study was to test this latter perspective in relation to auditory distraction by investigating whether ADHD-adults exhibit aberrant FC between DMN, VA/SN, and auditory networks.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Twelve minutes of resting-state fMRI data was collected from two adult groups: ADHD (<jats:italic>n</jats:italic> = 17) and controls (<jats:italic>n</jats:italic> = 17); from which the FC between predefined regions comprising the DMN, VA/SN, and auditory networks were analyzed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A weaker anticorrelation between the VA/SN and DMN was observed in ADHD. DMN and VA/SN hubs also exhibited aberrant FC with the auditory network in ADHD. Additionally, participants who displayed a stronger anticorrelation between the VA/SN and auditory network at rest, also performed better on a cognitively demanding behavioral task that involved ignoring a distracting auditory stimulus.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Results are consistent with the hypothesis that auditory distraction in ADHD is linked to aberrant interactions between DMN, VA/SN, and auditory systems. Our findings support models that implicate dysfunctional organization of the DMN and VA/SN in the disorder and encourage more research into sensory interactions with these major networks.</jats:p></jats:sec>