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Medientyp:
E-Artikel
Titel:
Anti-Viral Photodynamic Inactivation of T4-like Bacteriophage as a Mammalian Virus Model in Blood
Beteiligte:
Santos, Patrícia;
Gomes, Ana T. P. C.;
Lourenço, Leandro M. O.;
Faustino, Maria A. F.;
Neves, Maria G. P. M. S.;
Almeida, Adelaide
Erschienen:
MDPI AG, 2022
Erschienen in:International Journal of Molecular Sciences
Sprache:
Englisch
DOI:
10.3390/ijms231911548
ISSN:
1422-0067
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>The laboratorial available methods applied in plasma disinfection can induce damage in other blood components. Antimicrobial photodynamic therapy (aPDT) represents a promising approach and is approved for plasma and platelet disinfection using non-porphyrinic photosensitizers (PSs), such as methylene blue (MB). In this study, the photodynamic action of three cationic porphyrins (Tri-Py(+)-Me, Tetra-Py(+)-Me and Tetra-S-Py(+)-Me) towards viruses was evaluated under white light irradiation at an irradiance of 25 and 150 mW·cm−2, and the results were compared with the efficacy of the approved MB. None of the PSs caused hemolysis at the isotonic conditions, using a T4-like phage as a model of mammalian viruses. All porphyrins were more effective than MB in the photoinactivation of the T4-like phage in plasma. Moreover, the most efficient PS promoted a moderate inactivation rate of the T4-like phage in whole blood. Nevertheless, these porphyrins, such as MB, can be considered promising and safe PSs to photoinactivate viruses in blood plasma.</jats:p>