van der Vliet, Hans J. J.;
van Vonderen, Marit G. A.;
Molling, Johan W.;
Bontkes, Hetty J.;
Reijm, Martine;
Reiss, Peter;
van Agtmael, Michiel A.;
Danner, Sven A.;
van den Eertwegh, Alfons J. M.;
von Blomberg, B. Mary E.;
Scheper, Rik J.
Cutting Edge: Rapid Recovery of NKT Cells upon Institution of Highly Active Antiretroviral Therapy for HIV-1 Infection
Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Cutting Edge: Rapid Recovery of NKT Cells upon Institution of Highly Active Antiretroviral Therapy for HIV-1 Infection
Beteiligte:
van der Vliet, Hans J. J.;
van Vonderen, Marit G. A.;
Molling, Johan W.;
Bontkes, Hetty J.;
Reijm, Martine;
Reiss, Peter;
van Agtmael, Michiel A.;
Danner, Sven A.;
van den Eertwegh, Alfons J. M.;
von Blomberg, B. Mary E.;
Scheper, Rik J.
Erschienen:
The American Association of Immunologists, 2006
Beschreibung:
<jats:title>Abstract</jats:title>
<jats:p>CD1d-restricted NKT cells play important regulatory roles in various immune responses and are rapidly and selectively depleted upon infection with HIV-1. The cause of this selective depletion is incompletely understood, although it is in part due to the high susceptibility of CD4+ NKT cells to direct infection and subsequent cell death by HIV-1. Here, we demonstrate that highly active antiretroviral therapy (HAART) results in the rapid recovery of predominantly CD4− NKT cells with kinetics that are strikingly similar to those of mainstream T cells. As it is well known that the early recovery of mainstream T cells in response to HAART is due to their redistribution from tissues to the circulation, our data suggest that the selective depletion of circulating NKT cells is likely due to a combination of cell death and tissue sequestration and indicates that HAART can improve immune functions by reconstituting both conventional T cells and immunoregulatory NKT cells.</jats:p>