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Livraghi, Luca; Hanly, Joseph J; Van Bellghem, Steven M; Montejo-Kovacevich, Gabriela; van der Heijden, Eva SM; Loh, Ling Sheng; Ren, Anna; Warren, Ian A; Lewis, James J; Concha, Carolina; Hebberecht, Laura; Wright, Charlotte J; Walker, Jonah M; Foley, Jessica; Goldberg, Zachary H; Arenas-Castro, Henry; Salazar, Camilo; Perry, Michael W; Papa, Riccardo; Martin, Arnaud; McMillan, W Owen; Jiggins, Chris D

Cortex cis-regulatory switches establish scale colour identity and pattern diversity in Heliconius

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  • Medientyp: E-Artikel
  • Titel: Cortex cis-regulatory switches establish scale colour identity and pattern diversity in Heliconius
  • Beteiligte: Livraghi, Luca; Hanly, Joseph J; Van Bellghem, Steven M; Montejo-Kovacevich, Gabriela; van der Heijden, Eva SM; Loh, Ling Sheng; Ren, Anna; Warren, Ian A; Lewis, James J; Concha, Carolina; Hebberecht, Laura; Wright, Charlotte J; Walker, Jonah M; Foley, Jessica; Goldberg, Zachary H; Arenas-Castro, Henry; Salazar, Camilo; Perry, Michael W; Papa, Riccardo; Martin, Arnaud; McMillan, W Owen; Jiggins, Chris D
  • Erschienen: eLife Sciences Publications, Ltd, 2021
  • Erschienen in: eLife
  • Sprache: Englisch
  • DOI: 10.7554/elife.68549
  • ISSN: 2050-084X
  • Schlagwörter: General Immunology and Microbiology ; General Biochemistry, Genetics and Molecular Biology ; General Medicine ; General Neuroscience
  • Entstehung:
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  • Beschreibung: <jats:p>In <jats:italic>Heliconius</jats:italic> butterflies, wing colour pattern diversity and scale types are controlled by a few genes of large effect that regulate colour pattern switches between morphs and species across a large mimetic radiation. One of these genes, <jats:italic>cortex</jats:italic>, has been repeatedly associated with colour pattern evolution in butterflies. Here we carried out CRISPR knockouts in multiple <jats:italic>Heliconius</jats:italic> species and show that <jats:italic>cortex</jats:italic> is a major determinant of scale cell identity. Chromatin accessibility profiling and introgression scans identified <jats:italic>cis</jats:italic>-regulatory regions associated with discrete phenotypic switches. CRISPR perturbation of these regions in black hindwing genotypes recreated a yellow bar, revealing their spatially limited activity. In the <jats:italic>H. melpomene/timareta</jats:italic> lineage, the candidate CRE from yellow-barred phenotype morphs is interrupted by a transposable element, suggesting that <jats:italic>cis</jats:italic>-regulatory structural variation underlies these mimetic adaptations. Our work shows that <jats:italic>cortex</jats:italic> functionally controls scale colour fate and that its <jats:italic>cis</jats:italic>-regulatory regions control a phenotypic switch in a modular and pattern-specific fashion.</jats:p>
  • Zugangsstatus: Freier Zugang