Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

Medientyp: E-Artikel

Titel: Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

Beteiligte: Corbin, Brian D.; Seeley, Erin H.; Raab, Andrea; Feldmann, Joerg; Miller, Michael R.; Torres, Victor J.; Anderson, Kelsi L.; Dattilo, Brian M.; Dunman, Paul M.; Gerads, Russell; Caprioli, Richard M.; Nacken, Wolfgang; Chazin, Walter J.; Skaar, Eric P.

Erschienen: American Association for the Advancement of Science, 2008

Sprache: Englisch

ISSN: 0036-8075; 1095-9203

Schlagwörter: Reports

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Beschreibung: <p>Bacterial infection often results in the formation of tissue abscesses, which represent the primary site of interaction between invading bacteria and the innate immune system. We identify the host protein calprotectin as a neutrophil-dependent factor expressed inside Staphylococcus aureus abscesses. Neutrophil-derived calprotectin inhibited S. aureus growth through chelation of nutrient<tex-math>$\text{Mn}^{2+}$</tex-math>and<tex-math>$\text{Zn}^{2+}$</tex-math>: an activity that results in reprogramming of the bacterial transcriptome. The abscesses of mice lacking calprotectin were enriched in metal, and staphylococcal proliferation was enhanced in these metal-rich abscesses. These results demonstrate that calprotectin is a critical factor in the innate immune response to infection and define metal chelation as a strategy for inhibiting microbial growth inside abscessed tissue.</p>

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