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Medientyp:
E-Artikel
Titel:
Novel Cluster of α -interferon Gene Sequences in a Placental Cosmid DNA Library
Beteiligte:
Lund, Bjorn;
Edlund, Thomas;
Lindenmaier, Werner;
Ny, Tor;
Collins, John;
Lundgren, Erik;
Von Gabain, Alexander
Erschienen:
National Academy of Sciences of the United States of America, 1984
Erschienen in:Proceedings of the National Academy of Sciences of the United States of America
Sprache:
Englisch
ISSN:
0027-8424
Entstehung:
Anmerkungen:
Beschreibung:
<p>A human cosmid library was constructed and probed with a human α interferon (IFN-α ) cDNA clone. One clone giving a strong hybridizing signal was isolated and characterized. The cosmid DNA insert represents a section of the human genome containing three regions of IFN-α -like sequences. The DNA was characterized with restriction endonuclease mapping, thereby allowing comparison to similar linkage groups reported recently and determination of homologous regions on the known physical map. The three IFN-α -like sequences were analyzed by a partial sequence analysis. Mapping and sequence data establish this section as a not-yet-described cluster of IFN-α sequences in the human genome; however, a part of the section matches to some degree to a previously described genomic region. The region described here could represent genetic polymorphism or a duplicated segment.</p>