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Media type:
E-Book;
Thesis
Title:
Klonale Evolution und zytogenetische Evolutionsmuster bei Myelodysplastischen Syndromen (MDS) und sekundärer akuter myeloischer Leukämie nach MDS
Other titles:
Nebentitel: Clonal evolution and evolution patterns of myelodysplastic syndroms and acute leukemia following MDS
Description:
Myelodysplastic syndromes (MDS) are clonal stem cell disorders characterized by heterogeneous symptoms and disease progression based on a multistep pathogenesis. Genetic instability promotes the gradual or sudden accumulation of genetic aberrations and thus, the development of clonal evolution reflecting the progression of disease (Haase 2005). The objective of the present study was to describe evolution patterns and to assess the prognostic value of clonal evolution and its different patterns for the clinical course of patients with MDS and acute leukemia following MDS. Retrospectively, da...