OPA1 R445H mutation in optic atrophy associated with sensorineural deafness

Media type: E-Article
Title: OPA1 R445H mutation in optic atrophy associated with sensorineural deafness
Contributor: Amati‐Bonneau, Patrizia; Guichet, Agnès; Olichon, Aurélien; Chevrollier, Arnaud; Viala, Frédérique; Miot, Stéphanie; Ayuso, Carmen; Odent, Sylvie; Arrouet, Catherine; Verny, Christophe; Calmels, Marie‐Noelle; Simard, Gilles; Belenguer, Pascale; Wang, Jing; Puel, Jean‐Luc; Hamel, Christian; Malthièry, Yves; Bonneau, Dominique; Lenaers, Guy; Reynier, Pascal
imprint: Wiley, 2005
Published in: Annals of Neurology
Language: English
DOI: 10.1002/ana.20681
ISSN: 0364-5134; 1531-8249
Keywords: Neurology (clinical) ; Neurology
Origination:
Footnote:
Description: <jats:title>Abstract</jats:title><jats:p>The heterozygous R445H mutation in OPA1 was found in five patients with optic atrophy and deafness. Audiometry suggested that the sensorineural deafness resulted from auditory neuropathy. Skin fibroblasts showed hyperfragmentation of the mitochondrial network, decreased mitochondrial membrane potential, and adenosine triphosphate synthesis defect. In addition, OPA1 was found to be widely expressed in the sensory and neural cochlear cells of the guinea pig. Thus, optic atrophy and deafness may be related to energy defects due to a fragmented mitochondrial network. Ann Neurol 2005</jats:p>

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